Alexandersson R, Gustafsson P, Hedenstierna G, Rosen G
Arch Environ Health. 1986 Mar-Apr;41(2):85-9. doi: 10.1080/00039896.1986.9937414.
Twenty-three subjects exposed to naphthalene-diisocyanate (NDI, [mean air concentration 0.002-0.007 mg/m3]) were examined with regard to symptoms and pulmonary function. Irritation of the eyes, cough, and exertion dyspnea were more common in exposed subjects than in unexposed controls. Closing volume, as a percentage of vital capacity (CV%), was 6% higher than the reference value (P = .01) on Monday morning after 2 days with no exposure to NDI. The other lung function variables were normal. Two days of industrial exposure caused no further change in any lung function variable. The difference between measured and expected CV% increased with age in the exposed subjects. Five employees who had complained of severe symptoms during NDI exposure and who, therefore, had been transferred to other tasks with no exposure to NDI, displayed marked increases in CV% and a reduction in the forced vital capacity by an average of 0.6 L. Smokers and nonsmokers displayed similar lung function changes.
对23名接触萘二异氰酸酯（NDI，平均空气浓度为0.002 - 0.007毫克/立方米）的受试者进行了症状和肺功能检查。与未接触者相比，接触者中眼睛刺激、咳嗽和运动性呼吸困难更为常见。在停止接触NDI两天后的周一上午，作为肺活量百分比的闭合气量（CV%）比参考值高6%（P = 0.01）。其他肺功能变量均正常。两天的工业接触未导致任何肺功能变量进一步变化。在接触者中，实测CV%与预期CV%之间的差异随年龄增长而增加。五名在接触NDI期间抱怨有严重症状、因此被调至不接触NDI的其他岗位的员工，其CV%显著增加，用力肺活量平均减少0.6升。吸烟者和非吸烟者表现出相似的肺功能变化。
