Musk A W, Peters J M, DiBerardinis L, Murphy R L
J Occup Med. 1982 Oct;24(10):746-50.
One hundred seven subjects from a polyurethane plastic manufacturing plant have been followed over a five-year period with measurements of forced expiratory volume in 1 s (FEV1), and questionnaires on respiratory symptoms and smoking habits. Environmental concentrations of toluene diisocyanate and diphenyl methyl diisocyanate were extensively monitored to provide accurate estimates of the upper-limits of exposure of the subjects. Current mean levels of FEV1 in this population were higher than those predicted for healthy subjects. The five-year change in FEV1 did not exceed that expected from aging. No acute change in FEV1 could be demonstrated over the course of a Monday either before or after a two-week vacation. No improvement in ventilatory function was observed over the vacation period. The presence of cough or sputum was related to smoking but was not related to isocyanate exposure. The results indicate that exposure of workers to extremely low levels of isocyanates (time-weighted average concentrations of the order of 0.001 parts per million [ppm]) is not associated with chronic respiratory symptoms or effects on ventilatory capacity. The results suggest that isocyanates can be controlled to the point of eliminating effects as measured by these techniques.
在五年时间里，对一家聚氨酯塑料制造工厂的107名员工进行了跟踪研究，测量他们的一秒用力呼气量（FEV1），并就呼吸道症状和吸烟习惯进行问卷调查。对甲苯二异氰酸酯和二苯基甲基二异氰酸酯的环境浓度进行了广泛监测，以准确估计这些员工的接触上限。该人群目前的FEV1平均水平高于健康受试者的预测水平。FEV1的五年变化未超过衰老预期的变化。在为期两周的假期前后的任何一个周一，均未发现FEV1有急性变化。在假期期间未观察到通气功能有所改善。咳嗽或咳痰的出现与吸烟有关，但与异氰酸酯接触无关。结果表明，工人接触极低水平的异氰酸酯（时间加权平均浓度约为百万分之0.001 [ppm]）与慢性呼吸道症状或通气能力影响无关。结果表明，通过这些技术测量，异氰酸酯可以控制到消除影响的程度。
