Fatima Nosheen, Zaman Areeba, Zaman Sidra, Zaman Unaiza, Zaman Maseeh U Z
Department of Radiology, Aga Khan University Hospital, Karachi, Pakistan.
Department of Medicine, Sunny Down State Hospital, New York, USA.
Indian J Nucl Med. 2023 Jan-Mar;38(1):65-66. doi: 10.4103/ijnm.ijnm_88_22. Epub 2023 Feb 24.
Systemic mastocytosis (SM) is a relatively rare heterogeneous group of disorders characterized by uncontrolled proliferation and accumulation of clonal mast cells in one or more organs. Indolent SM is the most common variety. Less common variety is aggressive systemic mastocytosis (aSM) type with or without associated hematological neopalsm (AHN). Fludeoxyglucose (FDG) positron emission tomography/computed tomography has a limited role in aSM without AHN as these exhibit low FDG avidity. We are presenting a biopsy-proven case of aSM without AHN showing abnormally high FDG uptake in lesions involving skin, nodes, marrow, and muscles.
系统性肥大细胞增多症（SM）是一组相对罕见的异质性疾病，其特征为一个或多个器官中克隆性肥大细胞不受控制的增殖和积聚。惰性SM是最常见的类型。较不常见的类型是侵袭性系统性肥大细胞增多症（aSM），伴有或不伴有相关血液系统肿瘤（AHN）。氟脱氧葡萄糖（FDG）正电子发射断层扫描/计算机断层扫描在无AHN的aSM中作用有限，因为这些病变表现出低FDG摄取。我们报告一例经活检证实的无AHN的aSM病例，该病例显示累及皮肤、淋巴结、骨髓和肌肉的病变中FDG摄取异常增高。
