Department of Nuclear Medicine, PET centre, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Nuklearmedizin. 2022 Feb;61(1):58-61. doi: 10.1055/a-1650-9704. Epub 2021 Oct 29.
Mastocytosis is a clonal hematopoietic disorder characterized by proliferation of abnormal mast cells in various organs including the skin, digestive system, lymph nodes, and bone marrow. We report on a 75-year-old woman presenting with abdominal pain, vomiting, diarrhoea, myalgia, and weight loss. Abdominal CT showed hepatosplenomegaly with heterogeneous splenic parenchyma, lymphadenopathy, and osteopenia with areas of osteosclerosis but no primary tumour. An F-FDG PET/CT revealed an overall low metabolic activity of the lesions with a diffuse bone marrow involvement raising suspicion of a haematological neoplasm. Subsequently, bone marrow and peripheral blood examinations confirmed the diagnosis of aggressive systemic mastocytosis.
肥大细胞增多症是一种克隆性造血系统疾病，其特征是异常肥大细胞在皮肤、消化系统、淋巴结和骨髓等各种器官中增殖。我们报告了一例 75 岁女性，表现为腹痛、呕吐、腹泻、肌痛和体重减轻。腹部 CT 显示肝脾肿大，脾脏实质不均匀，淋巴结病，骨质疏松伴多处骨硬化，但无原发性肿瘤。F-FDG PET/CT 显示病变整体代谢活性低，弥漫性骨髓受累，提示血液系统恶性肿瘤。随后，骨髓和外周血检查证实了侵袭性系统性肥大细胞增多症的诊断。
