纳武单抗诱发的致死性心肌炎：一例报告
Nivolumab-induced fatal myocarditis: A case report.
作者信息
Bharathidasan Kavya, Abdelnabi Mahmoud, Abdelmalek John, Sekhon Jasmine, Butler William, Quirch Miguel, Sosa Erwin Argueta
机构信息
Internal Medicine Department Texas Tech University Health Science Center Lubbock Texas USA.
Cardiology Department Texas Tech University Health Science Center Lubbock Texas USA.
出版信息
Clin Case Rep. 2023 May 9;11(5):e7306. doi: 10.1002/ccr3.7306. eCollection 2023 May.
KEY CLINICAL MESSAGE
Baseline assessment and interval monitoring with a careful history, clinical examination, laboratory work-up, and noninvasive imaging modalities may be beneficial for early detection of immune checkpoint inhibitor-associated side effects.
ABSTRACT
Previous reports of immune checkpoint inhibitors' cardiotoxic effects include pericarditis, myocarditis, myocardial infarction, ventricular dysfunction, vasculitis, and electrical abnormalities. The authors report a case of acute heart failure caused by nivolumab-induced cardiotoxicity in a middle-aged man with advanced esophageal carcinoma with no previous cardiac history or significant cardiovascular risk factors.
关键临床信息
通过详细病史、临床检查、实验室检查及无创成像手段进行基线评估和定期监测，可能有助于早期发现免疫检查点抑制剂相关的副作用。
摘要
既往关于免疫检查点抑制剂心脏毒性作用的报告包括心包炎、心肌炎、心肌梗死、心室功能障碍、血管炎及电异常。作者报告了一例由纳武单抗引起心脏毒性导致急性心力衰竭的病例，患者为一名中年晚期食管癌男性，既往无心脏病史或明显心血管危险因素。
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