Niewenhuis R J, Meineke H A
Arch Androl. 1986;16(1):13-8. doi: 10.3109/01485018608986918.
The conditions under which capillaries and venules within the testes of most scrotum-bearing mammals become sensitive and/or resistant to cadmium are not clearly elucidated. Localized heat lesions were produced within the testes of rats to allow regrowth from surrounding Cd-sensitive vessels into the damaged areas. After 2, 4, or 8 weeks rats were given a subcutaneous injection of CdCl2 in saline (5 mg/kg) and were sacrificed 6 h later. Tissue samples were examined by both light and electron microscopy. No evidence of Cd sensitivity in regenerated vessels was present after 2 weeks, but the surrounding normal tissue did show typical Cd-related damage. By 8 weeks, vessels within the lesioned areas responded to Cd in a manner similar to those in the surrounding tissue. Newly grown testicular vessels do not demonstrate Cd sensitivity, but they develop it between 4 and 8 weeks.
大多数有阴囊的哺乳动物睾丸内的毛细血管和小静脉对镉变得敏感和/或耐受的条件尚未明确阐明。在大鼠睾丸内产生局部热损伤，以使周围对镉敏感的血管向受损区域再生。在2、4或8周后，给大鼠皮下注射盐水中的CdCl₂（5mg/kg），并在6小时后处死。通过光学显微镜和电子显微镜检查组织样本。2周后再生血管中没有镉敏感性的证据，但周围正常组织确实显示出典型的与镉相关的损伤。到8周时，损伤区域内的血管对镉的反应方式与周围组织中的血管相似。新生长的睾丸血管在4至8周之间不会表现出镉敏感性，但之后会发展出这种敏感性。
