He Qianxiong, Xiao Liuyi, Shi Yuanjiang, Li Wanrong, Xin Xiaorong
Department of Ophthalmology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Clinical Medicine School of Southwest Medical University, Southwest Medical University, Luzhou, Sichuan, China.
Front Pharmacol. 2023 Apr 26;14:1149708. doi: 10.3389/fphar.2023.1149708. eCollection 2023.
Ischemic retinal damage, a common condition associated with retinal vascular occlusion, glaucoma, diabetic retinopathy, and other eye diseases, threatens the vision of millions of people worldwide. It triggers excessive inflammation, oxidative stress, apoptosis, and vascular dysfunction, leading to the loss and death of retinal ganglion cells. Unfortunately, minority drugs are available for treating retinal ischemic injury diseases, and their safety are limited. Therefore, there is an urgent need to develop more effective treatments for ischemic retinal damage. Natural compounds have been reported to have antioxidant, anti-inflammatory, and antiapoptotic properties that can be used to treat ischemic retinal damage. In addition, many natural compounds have been shown to exhibit biological functions and pharmacological properties relevant to the treatment of cellular and tissue damage. This article reviews the neuroprotective mechanisms of natural compounds involve treating ischemic retinal injury. These natural compounds may serve as treatments for ischemia-induced retinal diseases.
缺血性视网膜损伤是一种与视网膜血管阻塞、青光眼、糖尿病视网膜病变及其他眼部疾病相关的常见病症，威胁着全球数百万人的视力。它引发过度炎症、氧化应激、细胞凋亡和血管功能障碍，导致视网膜神经节细胞的丧失和死亡。不幸的是，用于治疗视网膜缺血性损伤疾病的药物很少，且其安全性有限。因此，迫切需要开发更有效的缺血性视网膜损伤治疗方法。据报道，天然化合物具有抗氧化、抗炎和抗细胞凋亡特性，可用于治疗缺血性视网膜损伤。此外，许多天然化合物已被证明具有与治疗细胞和组织损伤相关的生物学功能和药理特性。本文综述了天然化合物治疗缺血性视网膜损伤的神经保护机制。这些天然化合物可能成为缺血性视网膜疾病的治疗方法。
