Université Paris Cité, INSERM UMRS 1266, Institute of Psychiatry and Neuroscience of Paris, GHU Paris Psychiatrie et Neurosciences, Paris, France.
Institute of Biology Paris Seine, Neuroscience Paris Seine, CNRS UMR 8246, INSERM U1130, Sorbonne Université, Paris, France.
Front Neural Circuits. 2023 Apr 27;17:1181032. doi: 10.3389/fncir.2023.1181032. eCollection 2023.
Hippocampal area CA2 plays a critical role in social recognition memory and has unique cellular and molecular properties that distinguish it from areas CA1 and CA3. In addition to having a particularly high density of interneurons, the inhibitory transmission in this region displays two distinct forms of long-term synaptic plasticity. Early studies on human hippocampal tissue have reported unique alteration in area CA2 with several pathologies and psychiatric disorders. In this review, we present recent studies revealing changes in inhibitory transmission and plasticity of area CA2 in mouse models of multiple sclerosis, autism spectrum disorder, Alzheimer's disease, schizophrenia and the 22q11.2 deletion syndrome and propose how these changes could underly deficits in social cognition observed during these pathologies.
海马体 CA2 区在社会识别记忆中起着关键作用，具有独特的细胞和分子特性，使其与 CA1 和 CA3 区区分开来。除了具有特别高的中间神经元密度外，该区域的抑制性传递显示出两种不同形式的长时程突触可塑性。对人类海马组织的早期研究报告称，几种病理学和精神障碍与 CA2 区的独特改变有关。在这篇综述中，我们介绍了最近的研究，这些研究揭示了多发性硬化症、自闭症谱系障碍、阿尔茨海默病、精神分裂症和 22q11.2 缺失综合征的小鼠模型中 CA2 区抑制性传递和可塑性的变化，并提出了这些变化如何在这些病理学中观察到的社会认知缺陷中起作用。
