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美洲心脏临床路径。加强决策支持系统以改善初级保健机构中的高血压和心血管疾病风险管理。

HEARTS in the Americas clinical pathway. Strengthening the decision support system to improve hypertension and cardiovascular disease risk management in primary care settings.

作者信息

Rosende Andres, DiPette Donald J, Martinez Ramon, Brettler Jeffrey W, Rodriguez Gonzalo, Zuniga Eric, Ordunez Pedro

机构信息

Department of Non-Communicable Diseases and Mental Health, Pan American Health Organization, Washington, DC, United States.

School of Medicine Columbia, University of South Carolina, Columbia, SC, United States.

出版信息

Front Cardiovasc Med. 2023 Apr 26;10:1102482. doi: 10.3389/fcvm.2023.1102482. eCollection 2023.

DOI:10.3389/fcvm.2023.1102482
PMID:37180772
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10169833/
Abstract

BACKGROUND

HEARTS in the Americas is the regional adaptation of the WHO Global HEARTS Initiative. It is implemented in 24 countries and over 2,000 primary healthcare facilities. This paper describes the results of a multicomponent, stepwise, quality improvement intervention designed by the HEARTS in the Americas to support advances in hypertension treatment protocols and evolution towards the Clinical Pathway.

METHODS

The quality improvement intervention comprised: 1) the use of the appraisal checklist to evaluate the current hypertension treatment protocols, 2) a peer-to-peer review and consensus process to resolve discrepancies, 3) a proposal of a clinical pathway to be considered by the countries, and 4) a process of review, adopt/adapt, consensus and approval of the clinical pathway by the national HEARTS protocol committee. A year later, 16 participants countries (10 and 6 from each cohort, respectively) were included in a second evaluation using the HEARTS appraisal checklist. We used the median and interquartile scores range and the percentages of the maximum possible total score for each domain as a performance measure to compare the results pre and post-intervention.

RESULTS

Among the eleven protocols from the ten countries in the first cohort, the baseline assessment achieved a median overall score of 22 points (ICR 18 -23.5; 65% yield). After the intervention, the overall score reached a median of 31.5 (ICR 28.5 -31.5; 93% yield). The second cohort of countries developed seven new clinical pathways with a median score of 31.5 (ICR 31.5 -32.5; 93% yield). The intervention was effective in three domains: 1. implementation (clinical follow-up intervals, frequency of drug refills, routine repeat blood pressure measurement when the first reading is off-target, and a straightforward course of action). 2. treatment (grouping all medications in a single daily intake and using a combination of two antihypertensive medications for all patients in the first treatment step upon the initial diagnosis of hypertension) and 3. management of cardiovascular risk (lower BP thresholds and targets based on CVD risk level, and the use of aspirin and statins in high-risk patients).

CONCLUSION

This study confirms that this intervention was feasible, acceptable, and instrumental in achieving progress in all countries and all three domains of improvement: implementation, blood pressure treatment, and cardiovascular risk management. It also highlights the challenges that prevent a more rapid expansion of HEARTS in the Americas and confirms that the main barriers are in the organization of health services: drug titration by non-physician health workers, the lack of long-acting antihypertensive medications, lack of availability of fixed-doses combination in a single pill and cannot use high-intensity statins in patients with established cardiovascular diseases. Adopting and implementing the HEARTS Clinical Pathway can improve the efficiency and effectiveness of hypertension and cardiovascular disease risk management programs.

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0762/10169833/067a811991cf/fcvm-10-1102482-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0762/10169833/9865aab3aeb2/fcvm-10-1102482-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0762/10169833/522bd411aa83/fcvm-10-1102482-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0762/10169833/6af972ca5af3/fcvm-10-1102482-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0762/10169833/067a811991cf/fcvm-10-1102482-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0762/10169833/9865aab3aeb2/fcvm-10-1102482-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0762/10169833/522bd411aa83/fcvm-10-1102482-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0762/10169833/6af972ca5af3/fcvm-10-1102482-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0762/10169833/067a811991cf/fcvm-10-1102482-g004.jpg
摘要

背景

“美洲心脏计划”(HEARTS in the Americas)是世界卫生组织全球HEARTS倡议的区域适应性项目。该项目在24个国家的2000多家初级医疗保健机构实施。本文介绍了美洲心脏计划设计的一项多组分、逐步推进的质量改进干预措施的成果,该措施旨在支持高血压治疗方案的进步并向临床路径发展。

方法

质量改进干预措施包括:1)使用评估清单来评估当前的高血压治疗方案;2)通过同行评审和达成共识的过程来解决差异;3)提出供各国考虑的临床路径;4)由国家心脏计划协议委员会对临床路径进行审查、采用/调整、达成共识和批准。一年后,16个参与国(分别来自每个队列的10个和6个)使用心脏计划评估清单进行了第二次评估。我们使用中位数和四分位间距分数范围以及每个领域的最大可能总分的百分比作为绩效指标来比较干预前后的结果。

结果

在第一个队列中10个国家的11个方案中,基线评估的总体中位数得分为22分(四分位间距18 - 23.5;达标率65%)。干预后,总体得分中位数达到31.5分(四分位间距28.5 - 31.5;达标率93%)。第二个队列的国家制定了7条新的临床路径,中位数得分为31.5分(四分位间距31.5 - 32.5;达标率93%)。该干预在三个领域有效:1. 实施(临床随访间隔、药物 refill频率、首次读数偏离目标时常规重复测量血压以及直接的行动方案)。2. 治疗(将所有药物合并为每日一次服用,并在高血压初诊时对所有患者在第一个治疗步骤中使用两种抗高血压药物联合治疗)和3. 心血管风险管理(根据心血管疾病风险水平降低血压阈值和目标,并在高危患者中使用阿司匹林和他汀类药物)。

结论

本研究证实,该干预措施是可行的、可接受的,并且有助于在所有国家以及改进的所有三个领域取得进展:实施、血压治疗和心血管风险管理。它还突出了阻碍美洲心脏计划更快扩展的挑战,并证实主要障碍在于卫生服务的组织:非医师卫生工作者进行药物滴定;缺乏长效抗高血压药物;缺乏单片固定剂量复方制剂;以及已确诊心血管疾病的患者无法使用高强度他汀类药物。采用和实施心脏计划临床路径可以提高高血压和心血管疾病风险管理项目的效率和效果。

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