Runge T M, Shapowal B L
Arch Int Pharmacodyn Ther. 1986 Apr;280(2):194-204.
Six trained domestic cats received a spectrum of polar to nonpolar cardiac glycosides: ouabain, digoxin or digitoxin with medication free intervals of four weeks. Significant (P less than 0.01) rate reduction (-19 +/- 8%) and prolongation of PR interval (+13 +/- 5%) occurred with ouabain and with digoxin (-18 +/- 5% and +13 +/- 3%) but not with digitoxin (-6 +/- 4% and +6 +/- 5%). However, rate corrected QS2 abbreviation was greater with digitoxin (-13 +/- 3%) than with ouabain (-8 +/- 3%) or digoxin (-10 +/- 5%). The findings indicate that in cats the polar cardiac glycosides ouabain and digoxin produce greater prolongation of A-V conduction while the nonpolar glycoside digitoxin produces greater abbreviation of QS2. Previously this finding was reported by the authors in guinea-pigs and in rabbits and has since been reported in intact rats, dogs, and in man by other authors. Investigators using nonintact subjects have not been able to demonstrate the finding. The differences may have clinical significance and suggest new insight into structural/activity relationships within the cardiac glycoside family.
哇巴因、地高辛或洋地黄毒苷，给药间隔为四周。使用哇巴因和地高辛时出现了显著（P小于0.01）的心率降低（-19±8%）和PR间期延长（+13±5%），而使用洋地黄毒苷时未出现（-6±4%和+6±5%）。然而，洋地黄毒苷导致的心率校正QS2缩短（-13±3%）比哇巴因（-8±3%）或地高辛（-10±5%）更明显。这些发现表明，在猫中，极性强心苷哇巴因和地高辛对房室传导的延长作用更强，而非极性苷洋地黄毒苷对QS2的缩短作用更强。此前，作者在豚鼠和兔子中报道过这一发现，此后其他作者也在完整的大鼠、狗和人类中报道过。使用非完整实验对象的研究人员未能证实这一发现。这些差异可能具有临床意义，并为强心苷家族内的结构/活性关系提供了新的见解。
