脾酪氨酸激酶（SYK）信号与心脑血管疾病有关。
Spleen tyrosine kinase (SYK) signals are implicated in cardio-cerebrovascular diseases.
作者信息
Li Mohan, Wang Pengbo, Zou Yuanming, Wang Wenbin, Zhao Yuanhui, Liu Mengke, Wu Jianlong, Zhang Ying, Zhang Naijin, Sun Yingxian
机构信息
Department of Cardiology, First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, Liaoning Province, People's Republic of China.
Institute of Health Sciences, China Medical University, 77 Puhe Road, Shenbei New District, Shenyang, 110001, Liaoning Province, People's Republic of China.
出版信息
Heliyon. 2023 Apr 22;9(5):e15625. doi: 10.1016/j.heliyon.2023.e15625. eCollection 2023 May.
Post-translational modifications regulate numerous biochemical reactions and functions through covalent attachment to proteins. Phosphorylation, acetylation and ubiquitination account for over 90% of all reported post-translational modifications. As one of the tyrosine protein kinases, spleen tyrosine kinase (SYK) plays crucial roles in many pathophysiological processes and affects the pathogenesis and progression of various diseases. SYK is expressed in tissues outside the hematopoietic system, especially the heart, and is involved in the progression of various cardio-cerebrovascular diseases, such as atherosclerosis, heart failure, diabetic cardiomyopathy, stroke and others. Knowledge on the role of SYK in the progress of cardio-cerebrovascular diseases is accumulating, and many related mechanisms have been discovered and validated. This review summarizes the role of SYK in the progression of various cardio-cerebrovascular diseases, and aims to provide a theoretical basis for future experimental and clinical research targeting SYK as a therapeutic option for these diseases.
翻译后修饰通过与蛋白质的共价连接来调节众多生化反应和功能。磷酸化、乙酰化和泛素化占所有已报道翻译后修饰的90%以上。作为酪氨酸蛋白激酶之一，脾酪氨酸激酶（SYK）在许多病理生理过程中起关键作用，并影响各种疾病的发病机制和进展。SYK在造血系统以外的组织中表达，尤其是心脏，并参与各种心脑血管疾病的进展，如动脉粥样硬化、心力衰竭、糖尿病心肌病、中风等。关于SYK在心脑血管疾病进展中的作用的知识正在积累，许多相关机制已被发现和验证。本综述总结了SYK在各种心脑血管疾病进展中的作用，旨在为未来以SYK为靶点治疗这些疾病的实验和临床研究提供理论依据。
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