Department of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin 300052, PR China.
Department of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin 300052, PR China.
Int Immunopharmacol. 2023 Jun;119:110307. doi: 10.1016/j.intimp.2023.110307. Epub 2023 May 12.
Acute kidney injury (AKI) is a common clinical kidney disease with a high mortality rate. AKI is caused by a variety of factors, including sepsis, ischemia, and nephrotoxic drugs, and can progress to chronic kidney disease and end-stage renal disease. Numerous studies have suggested that cytokines can be used as therapeutic targets for AKI. IL-17 is a pro-inflammatory cytokine that not only participates in the host defense and the development of autoimmune diseases but also is linked to AKI due to a variety of factors. This review will give an overview of the structure, signaling pathways, and biological functions of IL-17, as well as its role in AKI, to show that IL-17 is a potential target for the prevention and treatment of AKI.
急性肾损伤（AKI）是一种常见的临床肾脏疾病，死亡率较高。AKI 由多种因素引起，包括败血症、缺血和肾毒性药物，可进展为慢性肾脏病和终末期肾病。大量研究表明，细胞因子可用作 AKI 的治疗靶点。IL-17 是一种促炎细胞因子，不仅参与宿主防御和自身免疫性疾病的发展，而且由于多种因素与 AKI 有关。本综述将概述 IL-17 的结构、信号通路和生物学功能及其在 AKI 中的作用，以表明 IL-17 是预防和治疗 AKI 的潜在靶点。
