Department of Applied Physics, Bhilai Institute of Technology (Seth Balkrishan Memorial), Near Bhilai House, Durg, C.G, 491001, India.
Department of Applied Physics, Bhilai Institute of Technology (Seth Balkrishan Memorial), Near Bhilai House, Durg, C.G, 491001, India.
Chem Biol Interact. 2023 Aug 1;380:110537. doi: 10.1016/j.cbi.2023.110537. Epub 2023 May 12.
The rapid development of nanomedicine has increased the likelihood that manufactured nanoparticles will one day come into contact with people and the environment. A variety of academic fields, including engineering and the health sciences, have taken a keen interest in the development of nanotechnology. Any significant development in nanomaterial-based applications would depend on the production of functionalized nanoparticles, which are believed to have the potential to be used in fields like pharmaceutical and biomedical sciences. The functionalization of nanoparticles with particular recognition chemical moieties does result in multifunctional nanoparticles with greater efficacy while at the same time minimising adverse effects, according to early clinical studies. This is because of traits like aggressive cellular uptake and focused localization in tumours. To advance this field of inquiry, chemical procedures must be developed that reliably attach chemical moieties to nanoparticles. The structure-function relationship of these functionalized nanoparticles has been extensively studied as a result of the discovery of several chemical processes for the synthesis of functionalized nanoparticles specifically for drug delivery, cancer therapy, diagnostics, tissue engineering, and molecular biology. Because of the growing understanding of how to functionalize nanoparticles and the continued work of innovative scientists to expand this technology, it is anticipated that functionalized nanoparticles will play an important role in the aforementioned domains. As a result, the goal of this study is to familiarise readers with nanoparticles, to explain functionalization techniques that have already been developed, and to examine potential applications for nanoparticles in the biomedical sciences. This review's information is essential for the safe and broad use of functionalized nanoparticles, particularly in the biomedical sector.
纳米医学的迅速发展增加了人造纳米颗粒有朝一日将与人接触和进入环境的可能性。包括工程学和健康科学在内的各种学术领域都对纳米技术的发展产生了浓厚的兴趣。任何基于纳米材料的应用的重大发展都将取决于功能化纳米颗粒的生产，人们相信这些纳米颗粒有可能在制药和生物医学科学等领域得到应用。根据早期的临床研究，通过将特定识别化学基团功能化纳米颗粒确实可以得到具有更高疗效同时最小化不良反应的多功能纳米颗粒。这是因为这些纳米颗粒具有侵略性的细胞摄取和在肿瘤中的靶向定位等特性。为了推进这一研究领域，必须开发出可靠地将化学基团附着到纳米颗粒上的化学程序。由于发现了几种专门用于药物输送、癌症治疗、诊断、组织工程和分子生物学的合成功能化纳米颗粒的化学过程，这些功能化纳米颗粒的结构-功能关系已经得到了广泛的研究。由于人们对如何功能化纳米颗粒的理解不断加深，以及创新科学家不断努力扩展这项技术，预计功能化纳米颗粒将在上述领域发挥重要作用。因此，本研究的目的是使读者熟悉纳米颗粒，解释已经开发出的功能化技术，并探讨纳米颗粒在生物医学科学中的潜在应用。本综述的信息对于安全和广泛应用功能化纳米颗粒至关重要，特别是在生物医学领域。
