School of Engineering, China Pharmaceutical University, Nanjing, 211198, China.
Clinical Laboratory, Xiantao First People's Hospital, Xiantao, 433000, China.
Biomater Sci. 2023 Jun 27;11(13):4574-4582. doi: 10.1039/d3bm00239j.
Engineering versatile phototheranostics for multimodal diagnostic imaging and effective therapy has great potential in cancer treatment. However, developing an inherently versatile molecule is a huge challenge. In this work, a near-infrared organic dye (NRh) was synthesized and further bound with bovine serum albumin (BSA) to construct facile "one-for-all" phototheranostics (NRh-BSA NPs), which exhibited enhanced frequency upconversion luminescence (FUCL, = 850/825 nm) and excellent photoacoustic (PA) and photothermal properties ( = 808 nm). Additionally, the BSA-modified phototheranostics NRh-BSA NPs showed specific accumulation in the tumor region through passive targeting. Based on the FUCL/PA dual modal imaging-guidance, the NRh-BSA NPs not only can guarantee the accuracy of imaging of the U87MG tumor sites, but also can improve the therapeutic effect on ablating tumors without recurrence by photothermal therapy (PTT). Collectively, our work proposed a novel strategy to construct versatile phototheranostics with the unique FUCL/PA imaging-guided technique for accurate cancer theranostics.
工程多功能光热诊断用于多模态诊断成像和有效治疗在癌症治疗中有很大的潜力。然而，开发一种固有多功能的分子是一个巨大的挑战。在这项工作中，合成了一种近红外有机染料（NRh），并进一步与牛血清白蛋白（BSA）结合，构建了简便的“一应俱全”的光热诊断试剂（NRh-BSA NPs），其表现出增强的频上转换发光（FUCL，=850/825nm）和优异的光声（PA）和光热性能（=808nm）。此外，BSA 修饰的光热诊断试剂 NRh-BSA NPs 通过被动靶向在肿瘤区域表现出特异性聚集。基于 FUCL/PA 双模态成像引导，NRh-BSA NPs 不仅可以保证 U87MG 肿瘤部位成像的准确性，而且可以通过光热治疗（PTT）提高无复发消融肿瘤的治疗效果。总的来说，我们的工作提出了一种构建多功能光热诊断试剂的新策略，具有独特的 FUCL/PA 成像引导技术，用于精确的癌症治疗。
