Key Laboratory of Flexible Electronics & Institute of Advanced Materials, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing 211816, China.
Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, Nanjing 210023, China.
Biomater Sci. 2019 Sep 1;7(9):3609-3613. doi: 10.1039/c9bm00997c. Epub 2019 Jul 30.
Development of versatile phototheranostics is highly desirable for cancer theranostics. Herein, a novel organic conjugated polymer (named DPP-TT) with excellent optical properties was designed and prepared. Based on single-component DPP-TT, single DPP-TT NPs as versatile phototheranostics were developed by a simple nanoprecipitation method. The obtained NPs exhibited good water solubility, excellent biocompatibility, outstanding photostability, strong NIR-I light absorption, and appropriate NIR-II fluorescence emission. Importantly, such NPs presented high photothermal conversion efficiency. From the investigations performed in vitro and in vivo, it was observed that DPP-TT NPs show remarkable performance for cancer theranostics, benefiting from single 808 nm laser-induced tri-modal (NIR-II fluorescence/photoacoustic/thermal) imaging-guided photothermal therapy.
开发多功能光热治疗对于癌症的治疗诊断极具吸引力。在此，设计并制备了一种具有优异光学性能的新型有机共轭聚合物（命名为 DPP-TT）。基于单一组分 DPP-TT，通过简单的纳米沉淀法开发了单一组分 DPP-TT NPs 作为多功能光热治疗剂。所得到的 NPs 具有良好的水溶性、优异的生物相容性、出色的光稳定性、强的近红外-I 光吸收和合适的近红外-II 荧光发射。重要的是，这些 NPs 表现出高的光热转换效率。从体外和体内研究中观察到，DPP-TT NPs 表现出优异的癌症治疗诊断性能，受益于单 808nm 激光诱导的三模态（近红外-II 荧光/光声/热）成像引导光热治疗。
