肝素与人类血小板第4因子的结合。
Binding of heparin to human platelet factor 4.
作者信息
Cowan S W, Bakshi E N, Machin K J, Isaacs N W
出版信息
Biochem J. 1986 Mar 1;234(2):485-8. doi: 10.1042/bj2340485.
Abstract
Platelet factor 4 is a small protein (Mr 7756) from the alpha-granules of blood platelets which binds strongly to and neutralizes the anticoagulant properties of heparin. From an analysis of X-ray crystallographic data a model for the binding of platelet factor 4 to heparin is proposed.
摘要
血小板第4因子是一种来自血小板α颗粒的小蛋白（分子量7756），它能与肝素紧密结合并中和其抗凝特性。基于对X射线晶体学数据的分析，提出了血小板第4因子与肝素结合的模型。
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本文引用的文献
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The molecular size of the antithrombin-binding sequence in heparin.肝素中抗凝血酶结合序列的分子大小。
FEBS Lett. 1980 Aug 11;117(1):203-6. doi: 10.1016/0014-5793(80)80945-8.
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The structure of heparin oligosaccharide fragments with high anti-(factor Xa) activity containing the minimal antithrombin III-binding sequence. Chemical and 13C nuclear-magnetic-resonance studies.具有高抗（因子Xa）活性且包含最小抗凝血酶III结合序列的肝素寡糖片段的结构。化学和13C核磁共振研究。
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Dansyl (5-dimethylaminonaphthalene-1-sulphonyl)-heparin binds antithrombin III and platelet factor 4 at separate sites.丹磺酰（5-二甲基氨基萘-1-磺酰基）-肝素在不同位点结合抗凝血酶III和血小板第4因子。
Biochem J. 1981 May 15;196(2):649-51. doi: 10.1042/bj1960649.
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Carbohydr Res. 1982 Mar 1;100:393-410. doi: 10.1016/s0008-6215(00)81050-2.
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Evidence for a 3-O-sulfated D-glucosamine residue in the antithrombin-binding sequence of heparin.肝素抗凝血酶结合序列中存在3-O-硫酸化D-葡萄糖胺残基的证据。
Proc Natl Acad Sci U S A. 1980 Nov;77(11):6551-5. doi: 10.1073/pnas.77.11.6551.
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The antithrombin-binding sequence in heparin. Identification of an essential 6-O-sulfate group.肝素中抗凝血酶结合序列。一个必需的6-O-硫酸基团的鉴定。
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7
Binding of platelet factor 4 to heparin oligosaccharides.血小板因子4与肝素寡糖的结合。
Biochem J. 1983 Feb 1;209(2):455-60. doi: 10.1042/bj2090455.
8
Mechanism of the anticoagulant action of heparin.肝素抗凝作用的机制。
Mol Cell Biochem. 1982 Oct 29;48(3):161-82. doi: 10.1007/BF00421226.
9
X-ray diffraction analysis of crystals of bovine platelet factor 4.牛血小板因子4晶体的X射线衍射分析。
J Mol Biol. 1984 Jul 5;176(3):421-3. doi: 10.1016/0022-2836(84)90497-2.
10
Anticoagulant activities of heparin oligosaccharides and their neutralization by platelet factor 4.肝素寡糖的抗凝活性及其被血小板第4因子中和的作用
Biochem J. 1984 Mar 15;218(3):725-32. doi: 10.1042/bj2180725.
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