Département de medecine generale, Normandie Université, UNICAEN, 14000, Caen, France.
INSERM U1086 ANTICIPE, Normandie Université, UNICAEN, 14000, Caen, France.
Sci Rep. 2023 Apr 25;13(1):6723. doi: 10.1038/s41598-023-33943-0.
To investigate whether marital status is associated to long-term major fatal and non-fatal cardiovascular events in men and women from the Gubbio Population Study. The incidence of cardiovascular disease (CVD), including stroke and coronary heart disease (CHD) and CVD death together with all-cause mortality were analyzed. The analysis included 2832 persons (44% men, 54 ± 11 years old). Marital status was defined at entry as married (married or living conjugally) versus unmarried subjects (widowed, separated, divorced or single). Married and unmarried subjects did not differ concerning socio-demographic, anthropometric and biological variables at baseline. Over 191 months median follow-up, the incidence of CHD was lower among married versus unmarried women [HR: 0.63 (95% CI 0.41-0.96)] only; the same was true for CHD mortality [HR: 0.43 (95% CI 0.22-0.84)] and all-cause mortality [HR: 0.75 (95% CI 0.59-0.96)] independently of traditional risk factors (age, SBP, total and HDL cholesterol, cigarette smoke and BMI). In men, marital status was not associated to any of the investigated outcomes. In primary care, marital status should be investigated as it can be associated with long-term CHD and all-cause incidence and mortality risks among women.
为了调查婚姻状况是否与男性和女性的长期主要致命和非致命心血管事件有关，我们对 Gubbio 人群研究中的患者进行了研究。分析了心血管疾病（CVD）的发生率，包括中风和冠心病（CHD）以及 CVD 死亡和全因死亡率。该分析包括 2832 人（44%为男性，54±11 岁）。婚姻状况在入组时定义为已婚（已婚或同居）与未婚（丧偶、分居、离婚或单身）。已婚和未婚患者在基线时的社会人口统计学、人体测量学和生物学变量方面没有差异。在 191 个月的中位随访期间，与未婚女性相比，已婚女性的 CHD 发生率较低[HR：0.63（95% CI 0.41-0.96）]；CHD 死亡率[HR：0.43（95% CI 0.22-0.84）]和全因死亡率[HR：0.75（95% CI 0.59-0.96）]也是如此，独立于传统危险因素（年龄、SBP、总胆固醇和 HDL 胆固醇、吸烟和 BMI）。在男性中，婚姻状况与任何研究结果均无关。在初级保健中，应调查婚姻状况，因为它可能与女性的长期 CHD 和全因发病和死亡风险有关。
