Lu Ting, Chen Zhiwei, Cao Yu, Ao Ling, Li Zisheng, Gu Xiaoyi, Ren Xingqian, Wang Yixuan, Zhang Gaoli, Xiang Dejuan, Chen Min, Cai Dachuan, Hu Peng, Zhang Dazhi, Peng Mingli, Shi Xiaofeng, Ren Hong
Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
The People's Hospital of Tongliang District, Chongqing, China.
J Med Virol. 2023 Apr;95(4):e28730. doi: 10.1002/jmv.28730.
People living with HIV (PLWH) have poor outcomes from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); vaccination reduces the associated mortality. The humoral immune response dynamics after booster inactivated vaccinations in PLWH remain unclear. In this longitudinal observational study, 100 PLWH after primary inactivated SARS-CoV-2 vaccination were consecutively recruited and followed up. After booster vaccination (BV), neutralizing antibodies (NAbs) were detected at 1 month from all the PLWH, and the titer increased sixfold compared to that associated with the primary vaccination (PV), similar to that in healthy controls after BV. The NAbs titer declined over time after BV, but remained higher at 6 months than after PV. The NAbs response was elevated after BV with CD4 count <200 cells/μL, it was the poorest among the different CD4 cell count subgroups. Similar results were observed for anti-RBD-IgG responses. Moreover, RBD-specific MBCs were significantly elevated after BV in PLWH. No serious AEs were observed after BV in PLWH. In conclusion, booster inactivated SARS-CoV-2 vaccination is well tolerated and can elicit robust and durable humoral responses in PLWH. PLWH may benefit from a third dose of the inactivated vaccine.
感染人类免疫缺陷病毒（HIV）的人（PLWH）感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）后的预后较差；接种疫苗可降低相关死亡率。PLWH接种加强针灭活疫苗后的体液免疫反应动态仍不清楚。在这项纵向观察研究中，连续招募并随访了100名初次接种SARS-CoV-2灭活疫苗后的PLWH。加强疫苗接种（BV）后，在所有PLWH中于1个月时检测到中和抗体（NAbs），其滴度与初次接种（PV）相比增加了六倍，与BV后健康对照中的情况相似。BV后NAbs滴度随时间下降，但在6个月时仍高于PV后。BV后CD4计数<200个细胞/μL的PLWH的NAbs反应升高，在不同CD4细胞计数亚组中是最差的。抗RBD-IgG反应也观察到类似结果。此外，PLWH在BV后RBD特异性记忆B细胞显著升高。PLWH在BV后未观察到严重不良事件。总之，加强针SARS-CoV-2灭活疫苗耐受性良好，可在PLWH中引发强烈且持久的体液反应。PLWH可能从第三剂灭活疫苗中获益。
