Levine D H, Madyastha P R
Am J Perinatol. 1986 Jul;3(3):231-3. doi: 10.1055/s-2007-999873.
An unselected population of newborn infants at a tertiary perinatal center was the subject of an investigation of isoimmune neonatal neutropenia (INN) to determine the incidence of the disorder and further characterize its clinical and immunologic aspects. We screened 1465 consecutively born infants for neutropenia on the first day of life, and evaluated those with neutropenia for the presence of antineutrophil antibodies utilizing EDTA-microagglutination and indirect immunofluorescence. Of the 16 infants with persistent neutropenia, 3 were confirmed to have INN, representing 2/1000 live births and 1.5% of special care nursery admissions during the period. INN is not a rare disorder and should be considered in the evaluation of all infants with neutropenia, with or without infection. Our rapidly expanding knowledge of the neutrophil-specific antigen system is refining our ability to diagnose and treat immune neutropenias.
在一家三级围产期中心，对未经过筛选的新生儿群体进行了一项关于同种免疫性新生儿中性粒细胞减少症（INN）的调查，以确定该疾病的发病率，并进一步描述其临床和免疫学特征。我们在出生第一天对1465名连续出生的婴儿进行了中性粒细胞减少症筛查，并利用乙二胺四乙酸（EDTA）微凝集试验和间接免疫荧光法评估了患有中性粒细胞减少症的婴儿是否存在抗中性粒细胞抗体。在16名持续性中性粒细胞减少症婴儿中，有3名被确诊为INN，占该时期活产儿的2/1000，占特别护理病房入院人数的1.5%。INN并非罕见疾病，在评估所有中性粒细胞减少症婴儿时，无论有无感染，均应考虑该病。我们对中性粒细胞特异性抗原系统的快速扩展的认识正在提高我们诊断和治疗免疫性中性粒细胞减少症的能力。
