Wang Xiangdong, Zhu Dongpo, Peng Leilei, Gao Yan, Li Xiaodong
Department of Blood Purification, Baoding People's Hospital, Baoding, 071030, People's Republic of China.
Department of Internal Medicine, Baoding People's Hospital, Baoding, 071030, People's Republic of China.
Int J Gen Med. 2023 May 8;16:1705-1712. doi: 10.2147/IJGM.S412230. eCollection 2023.
One of the earliest echocardiographic features of the left ventricle explored extensively was left ventricular hypertrophy (LVH). Numerous studies have identified a few risk factors for LVH, however, there are few for people with diabetic kidney disease (DKD). Therefore, we evaluated the risk factors in DKD patients with LVH by analyzing laboratory data and clinical traits.
In total, 500 DKD patients in the Baoding area from February 2016 and June 2020 were admitted and classified as an experimental group (240 cases, LVH group) and a control group (260 cases, non-LVH group). The clinical parameters and laboratory tests of the participants were collected and analyzed retrospectively.
Compared with the control group, low-density lipoprotein (LDL), body mass index (BMI), intact parathyroid hormone (iPTH), systolic blood pressure, and 24-hour urine protein were higher in the experimental group (all P<0.01). Multivariable logistic regression analysis results confirmed that high BMI (OR=1.332, 95% CI 1.016-1.537, P=0.006), LDL (OR=1.279, 95% CI 1.008-1.369, P=0.014) and 24-hour urine proteins (OR=1.446, 95% CI 1.104-1.643, P=0.016) were statistically significant. The ROC analysis illustrated that the optimum cutoff value of BMI, LDL, and 24-hour urine proteins for diagnosis of LVH in patients with DKD was 27.36 kg/m, 4.18 mmol/L, and 1.42 g respectively.
The increase in BMI, LDL, and 24-hour urine proteins quantification are independent risk factors for LVH in patients with DKD.
左心室肥厚（LVH）是最早被广泛研究的超声心动图特征之一。众多研究已确定了一些LVH的危险因素，然而，针对糖尿病肾病（DKD）患者的危险因素却很少。因此，我们通过分析实验室数据和临床特征来评估DKD合并LVH患者的危险因素。
2016年2月至2020年6月期间，保定市共收治500例DKD患者，分为实验组（240例，LVH组）和对照组（260例，非LVH组）。回顾性收集并分析参与者的临床参数和实验室检查结果。
与对照组相比，实验组的低密度脂蛋白（LDL）、体重指数（BMI）、全段甲状旁腺激素（iPTH）、收缩压和24小时尿蛋白水平更高（均P<0.01）。多因素logistic回归分析结果证实，高BMI（OR=1.332，95%CI 1.016-1.537，P=0.006）、LDL（OR=1.279，95%CI 1.008-1.369，P=0.014）和24小时尿蛋白（OR=1.446，95%CI 1.104-1.643，P=0.016）具有统计学意义。ROC分析表明，BMI、LDL和24小时尿蛋白诊断DKD患者LVH的最佳截断值分别为27.36 kg/m、4.18 mmol/L和1.42 g。
BMI、LDL升高及24小时尿蛋白定量增加是DKD患者LVH的独立危险因素。
