临床器官移植中的药理免疫抑制。对四种药物的观察：环孢素A、阿斯塔5122（西替明）、卡拉胶和盐酸异丙嗪。
Pharmacological immunosuppression in clinical organ grafting. Observations on four agents: cyclosporin A, Asta 5122 (cytimun), lambda carrageenan and promethazine hydrochloride.
作者信息
Calne R Y
出版信息
Clin Exp Immunol. 1979 Jan;35(1):1-9.
In this article I have attempted to summarize experiments on four agents investigated for immunosuppressive activity in experimental and clinical organ grafting. The difficulty of finding a suitable laboratory model relevant to man has been demonstrated in this experience. A cyclophosphamide-derivative, Asta-5122 (cytimun), has only a marginally superior immunosuppressive activity in a dog with a renal allograft compared with cyclophosphamide and is much inferior to azathioprine. This agent, however, appears to be valuable in clinical practice in patients with liver grafts. A combination of lambda carrageenan, promethazine hydrochloride and imuran has profound immunosuppressive activity in the same canine model, but proved to be both ineffective and potentially toxic in a limited trial in man. The fungal cyclic peptide, cyclosporin A, has been shown to be an extremely powerful immunosuppressive agent and remarkably non-toxic in dogs with renal allografts and pigs with orthotopic heart grafts. This agent is currently being investigated as an immunosuppressant in patients with organ grafts.
在本文中，我试图总结针对四种药物开展的实验，这些药物在实验性和临床器官移植中被研究其免疫抑制活性。此次经历已证明找到一个与人类相关的合适实验室模型存在困难。一种环磷酰胺衍生物，Asta - 5122（环磷酰胺），在同种异体肾移植犬中，其免疫抑制活性仅略优于环磷酰胺，且远低于硫唑嘌呤。然而，该药物在肝移植患者的临床实践中似乎具有价值。在同一犬类模型中，λ - 角叉菜胶、盐酸异丙嗪和硫唑嘌呤的组合具有显著的免疫抑制活性，但在一项小型人体试验中被证明既无效又有潜在毒性。真菌环肽环孢素A已被证明是一种极其强大的免疫抑制剂，在同种异体肾移植犬和原位心脏移植猪中具有显著的低毒性。目前正在对该药物作为器官移植患者的免疫抑制剂进行研究。
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