用环孢素A治疗的猪原位心脏移植的长期存活

Prolonged survival of pig orthotopic heart grafts treated with cyclosporin A.

作者信息

Calne R Y, White D J, Rolles K, Smith D P, Herbertson B M

出版信息

Lancet. 1978 Jun 3;1(8075):1183-5. doi: 10.1016/s0140-6736(78)90971-6.

Abstract

Cyclosporin A was given to pigs receiving orthotopic cardiac allografts from donors mismatched at the major locus. Median survival in 20 control pigs was only 6 days; in 5 pigs given cyclosporin A at 15 mg/kg on 3 days median survival was 22 days; and when 6 animals were given 25 mg/kg intramuscularly for 2 days and then orally median survival is greater than 68 days, with 4 animals still alive.

摘要

将环孢素A给予接受来自主要位点不匹配供体的原位心脏同种异体移植的猪。20只对照猪的中位存活时间仅为6天；5只猪在3天内以15mg/kg的剂量给予环孢素A，中位存活时间为22天；当6只动物肌肉注射25mg/kg，持续2天，然后改为口服时，中位存活时间超过68天，有4只动物仍然存活。