Akbar Adjar Yusrandi, Cui Zhen-Yang, Hsu Che-Jui, Li Yan-Zhang, Rahman Ferry Fadzlul, Xia Chunqiu, Yang Ai-Lun, Lee Shin-Da
Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung, Taiwan.
Department of Biology Education, University of Muhammadiyah Malang, Malang, Indonesia.
Front Cardiovasc Med. 2023 Apr 27;10:1138705. doi: 10.3389/fcvm.2023.1138705. eCollection 2023.
This review aims to summarize the antiapoptotic, pro-survival, and antifibrotic effects of exercise training in hypertensive hearts.
Keyword searches were conducted in PubMed, Web of Science, and Scopus in May 2021. Research published in English on the effects of exercise training on the apoptosis, survival, and fibrosis pathways in hypertension was included. The CAMARADES checklist was used to determine the quality of the studies. Two reviewers independently implemented predesigned protocols for the search and selection of studies, the assessment of study quality, and the evaluation of the strength of evidence.
Eleven studies were included after selection. The duration of the exercise training ranged from 5 to 27 weeks. Nine studies showed that exercise training improved cardiac survival rates by increasing IGF-1, IGF-1 receptor, p-PI3K, Bcl-2, HSP 72, and p-Akt. Furthermore, 10 studies showed that exercise training reduced apoptotic pathways by downregulating Bid, t-Bid, Bad, Bak, Bax, TNF, and FADD. Finally, two studies reported the modification and subsequent improvement of physiological characteristics of fibrosis and decreased MAPK p38 and PTEN levels by exercise training in the left ventricle of the heart.
The findings of the review showed that exercise training could improve cardiac survival rates and attenuate cardiac apoptotic and fibrotic pathways in hypertension, suggesting that exercise training could act as a therapeutic approach to prevent hypertension-induced cardiac apoptosis and fibrosis.
https://www.crd.york.ac.uk, identifier: CRD42021254118.
本综述旨在总结运动训练对高血压心脏的抗凋亡、促生存和抗纤维化作用。
于2021年5月在PubMed、Web of Science和Scopus中进行关键词检索。纳入以英文发表的关于运动训练对高血压患者细胞凋亡、生存及纤维化通路影响的研究。使用CAMARADES清单来确定研究质量。两名评审员独立执行预先设计的方案，用于检索和筛选研究、评估研究质量以及评价证据强度。
筛选后纳入11项研究。运动训练的持续时间为5至27周。9项研究表明，运动训练通过增加胰岛素样生长因子-1（IGF-1）、IGF-1受体、磷酸化磷脂酰肌醇-3激酶（p-PI3K）、B细胞淋巴瘤-2（Bcl-2）、热休克蛋白72（HSP 72）和磷酸化蛋白激酶B（p-Akt）来提高心脏存活率。此外，10项研究表明，运动训练通过下调Bid、截短型Bid（t-Bid）、Bad、Bak、Bax、肿瘤坏死因子（TNF）和FADD来减少凋亡通路。最后，两项研究报告了运动训练对心脏纤维化生理特征的改善以及左心室中丝裂原活化蛋白激酶p38（MAPK p38）和磷酸酶及张力蛋白同源物（PTEN）水平的降低。
该综述的结果表明，运动训练可以提高高血压患者的心脏存活率，并减轻心脏凋亡和纤维化通路，这表明运动训练可作为一种治疗方法来预防高血压引起的心脏凋亡和纤维化。
