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不明原因发热的小儿心脏移植术后真菌感染的诊断:Tc-UBI SPECT/CT和F-FDG PET/CT的作用

Diagnosis of Fungal Infection () After Heart Transplantation in a Pediatric Case with Fever of Unknown Origin: Role of Tc-UBI SPECT/CT and F-FDG PET/CT.

作者信息

Malek Hadi, Hedayati Raheleh, Maghsudi Mahdi, Yaghoobi Nahid

机构信息

Cardiovascular Interventional Research Center, Department of Nuclear Medicine, Rajaei Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, Iran.

Department of Nuclear Medicine, Hazrate Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

出版信息

Nucl Med Mol Imaging. 2023 Jun;57(3):155-158. doi: 10.1007/s13139-022-00781-3. Epub 2022 Nov 2.

Abstract

The diagnosis of patients with fever of unknown origin (FUO) in pediatric heart transplantation is a challenging medical problem. The physician should differentiate between rejections, infections, malignancy, adrenal insufficiency, and drug fever. Immunosuppressive therapy in these patients exposes them to a high risk of developing a post-transplantation fungal infection. In this case, we discuss the diagnostic contribution of the Tc-UBI scan and F-FDG PET scan for diagnosis of fungal infection causing FUO in these patients.

摘要

小儿心脏移植中不明原因发热(FUO)患者的诊断是一个具有挑战性的医学问题。医生应区分排斥反应、感染、恶性肿瘤、肾上腺功能不全和药物热。这些患者的免疫抑制治疗使他们面临发生移植后真菌感染的高风险。在本病例中,我们讨论了Tc-UBI扫描和F-FDG PET扫描对诊断这些患者中导致FUO的真菌感染的诊断价值。

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本文引用的文献

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Current state of pediatric cardiac transplantation.小儿心脏移植的现状
Ann Cardiothorac Surg. 2018 Jan;7(1):31-55. doi: 10.21037/acs.2018.01.07.
4
FDG-PET in cardiac infections.FDG-PET 在心脏感染中的应用。
Semin Nucl Med. 2013 Sep;43(5):377-95. doi: 10.1053/j.semnuclmed.2013.04.003.
6
Specificity of 99mTc-UBI for detecting infection foci in patients with fever in study.
Nucl Med Commun. 2010 Oct;31(10):889-95. doi: 10.1097/MNM.0b013e32833d96d1.
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Fungal infection in heart transplant recipients with severe sepsis: single-center experience.
Transplant Proc. 2010 Apr;42(3):952-4. doi: 10.1016/j.transproceed.2010.02.049.
8
Fever of unknown origin in solid organ transplant recipients.实体器官移植受者的不明原因发热
Infect Dis Clin North Am. 2007 Dec;21(4):1033-54, ix-x. doi: 10.1016/j.idc.2007.09.001.

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