鹅去氧胆酸对乙炔雌二醇诱导的大鼠胆汁脂质分泌变化的影响。
Effect of chenodeoxycholic acid on the alterations of biliary lipid secretion induced by ethynylestradiol in the rat.
作者信息
Bonazzi P, Novelli G, Galeazzi R
出版信息
Br J Exp Pathol. 1986 Jun;67(3):341-8.
The role of chenodeoxycholic acid (CDCA) in modifying the biliary secretory alterations induced by ethynylestradiol (EE) was evaluated in male Sprague-Dawley rats. Bile flow and bile acid output were both decreased in rats given EE either alone or with CDCA (EE + CDCA) whereas cholesterol output showed a significant decrease only in animals given the combined treatment. The output of phospholipids remained unchanged in all groups. As a result the lithogenic index was significantly decreased in EE + CDCA-treated rats. In urine, the total bile acid excretion was significantly increased in EE + CDCA-treated animals. The data indicate that in the rat, biliary secretory failure induced by EE is not modified by CDCA, but that CDCA may prevent the increase of biliary cholesterol saturation caused by EE.
在雄性斯普拉格-道利大鼠中评估了鹅去氧胆酸（CDCA）在改变乙炔雌二醇（EE）诱导的胆汁分泌改变方面的作用。单独给予EE或给予EE与CDCA联合用药（EE + CDCA）的大鼠胆汁流量和胆汁酸输出均降低，而仅在接受联合治疗的动物中胆固醇输出显著降低。所有组中磷脂的输出保持不变。结果，EE + CDCA治疗的大鼠的成石指数显著降低。在尿液中，EE + CDCA治疗的动物总胆汁酸排泄显著增加。数据表明，在大鼠中，EE诱导的胆汁分泌衰竭未被CDCA改变，但CDCA可能预防EE引起的胆汁胆固醇饱和度增加。
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