School of Chemistry, Monash University, Clayton, 3800, Victoria, Australia.
School of Chemistry, University of Melbourne, Parkville, 3010, Victoria, Australia.
Angew Chem Int Ed Engl. 2023 Jul 17;62(29):e202303869. doi: 10.1002/anie.202303869. Epub 2023 Jun 6.
Dual nucleophilic phosphine photoredox catalysis is yet to be developed due to facile oxidation of the phosphine organocatalyst to the phosphoranyl radical cation. Herein, we report a reaction design that avoids this event and exploits traditional nucleophilic phosphine organocatalysis with photoredox catalysis to allow the Giese coupling with ynoates. The approach has good generality, while its mechanism is supported by cyclic voltametric, Stern-Volmer quenching, and interception studies.
双亲核膦光氧化还原催化由于膦有机催化剂容易氧化为磷翁自由基阳离子而尚未发展。在此，我们报告了一种避免这种情况的反应设计，并利用光氧化还原催化与传统亲核膦有机催化相结合，使 Giese 与 ynoate 的偶联反应得以进行。该方法具有很好的通用性，其机制得到了循环伏安法、Stern-Volmer 猝灭和拦截研究的支持。
