早产儿新生儿阿片类药物戒断综合征的特征与结局：当代一项回顾性队列研究
Characteristics and outcomes of neonatal opioid withdrawal syndrome in preterm infants: a retrospective cohort study in the current era.
作者信息
Heyward Alicia, Minich Nori, Hoffman Adriana C, Hibbs Anna Maria, Zhao Lulu, Crowley Moira
机构信息
Division of Neonatology, University Hospitals Rainbow Babies & Children's Hospital, Cleveland, OH, USA.
Case Western Reserve University School of Medicine, Cleveland, OH, USA.
出版信息
J Perinatol. 2023 Jul;43(7):909-915. doi: 10.1038/s41372-023-01672-x. Epub 2023 May 15.
OBJECTIVE
Compare Neonatal Opioid Withdrawal Syndrome (NOWS) in preterm and term infants.
STUDY DESIGN
Single center, retrospective chart review of all in-utero opioid exposed infants born between 2014 and 2019. Withdrawal symptoms were assessed using Modified Finnegan Assessment Tool.
RESULTS
Thirteen preterm (PT), 72 late preterm (LPT), and 178 term infants were included. Preterm and LPT compared to term infants had lower peak Finnegan scores (9/9 vs. 12) and received less pharmacologic treatment (23.1/44.4 vs. 66.3%). Similar onset, peak symptoms, and treatment duration was observed in LPT and term infants.
CONCLUSIONS
Preterm and LPT infants have lower Finnegan scores and require less pharmacologic therapy for NOWS. It is unclear if this is because our current assessment tool does not capture their symptoms or if they truly have less withdrawal. Onset of NOWS is similar in LPT and term infant, thus LPT infants do not require prolonged hospital monitoring for NOWS.
目的
比较早产儿和足月儿的新生儿阿片类药物戒断综合征（NOWS）。
研究设计
对2014年至2019年间出生的所有宫内暴露于阿片类药物的婴儿进行单中心回顾性病历审查。使用改良的芬尼根评估工具评估戒断症状。
结果
纳入13例早产儿（PT）、72例晚期早产儿（LPT）和178例足月儿。与足月儿相比，早产儿和晚期早产儿的芬尼根评分峰值较低（9/9对12），接受药物治疗的比例较低（23.1/44.4对66.3%）。晚期早产儿和足月儿的发病时间、症状峰值和治疗持续时间相似。
结论
早产儿和晚期早产儿的芬尼根评分较低，NOWS所需的药物治疗较少。目前尚不清楚这是因为我们当前的评估工具未能捕捉到他们的症状，还是他们的戒断反应确实较轻。晚期早产儿和足月儿的NOWS发病时间相似，因此晚期早产儿不需要因NOWS而延长住院监测时间。
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