Division of General Academic Pediatrics, MassGeneral Hospital for Children, 125 Nashua St #8630, USA.
Yale School of Medicine, Department of Pediatrics, 333 Cedar St., PO Box 208064, New Haven, CT, 06520-8064, USA.
Semin Fetal Neonatal Med. 2019 Apr;24(2):115-120. doi: 10.1016/j.siny.2019.01.003. Epub 2019 Jan 28.
Infants with in-utero opioid exposure are most commonly assessed using the Finnegan Neonatal Abstinence Scoring System (FNASS) or a modified version of that tool. Traditionally, the purpose of these tools has been to characterize the extent of withdrawal signs to guide the pharmacologic treatment for infants with neonatal opioid withdrawal syndrome (NOWS). In the past decade however, in response to some of the limitations of the FNASS tool, there has been an increasing emphasis on developing novel assessment tools not based on the FNASS in addition to the promotion of non-pharmacologic treatment options as the first line treatment for infants with opioid exposure. Additionally, several prediction tools that may be useful in determining which patients are at high or low risk for receiving pharmacologic therapy have been developed. In this review, we will evaluate the clinical utility of these novel tools and will consider new avenues for future research.
胎儿期阿片类物质暴露的婴儿通常使用芬内根新生儿戒断评分系统(FNASS)或其改良版本进行评估。传统上,这些工具的目的是描述戒断症状的严重程度,以指导新生儿阿片类戒断综合征(NOWS)婴儿的药物治疗。然而,在过去十年中,针对 FNASS 工具的一些局限性,人们越来越重视开发新的评估工具,这些工具不基于 FNASS,此外还提倡将非药物治疗作为阿片类物质暴露婴儿的一线治疗。此外,还开发了一些预测工具,可能有助于确定哪些患者接受药物治疗的风险高或低。在这篇综述中,我们将评估这些新工具的临床实用性,并考虑未来研究的新途径。