Vasilatis Demitria M, Lucchesi Christopher A, Ghosh Paramita M
Department of Urologic Surgery, School of Medicine, University of California Davis, Sacramento, CA 95718, USA.
Veterans Affairs (VA)-Northern California Healthcare System, Mather, CA 95655, USA.
Biomedicines. 2023 Apr 5;11(4):1100. doi: 10.3390/biomedicines11041100.
Dogs are one of few species that naturally develop prostate cancer (PCa), which clinically resembles aggressive, advanced PCa in humans. Moreover, PCa-tumor samples from dogs are often androgen receptor (AR)-negative and may enrich our understanding of AR-indifferent PCa in humans, a highly lethal subset of PCa for which few treatment modalities are available This narrative review discusses the molecular similarities between dog PCa and specific human-PCa variants, underscoring the possibilities of using the dog as a novel pre-clinical animal model for human PCa, resulting in new therapies and diagnostics that may benefit both species.
狗是少数能自然发生前列腺癌（PCa）的物种之一，其临床症状与人类侵袭性、晚期PCa相似。此外，狗的PCa肿瘤样本通常为雄激素受体（AR）阴性，这可能有助于我们加深对人类AR不敏感PCa的理解，AR不敏感PCa是PCa中一个高度致命的亚群，目前可用的治疗方式很少。这篇叙述性综述讨论了狗PCa与特定人类PCa变体之间的分子相似性，强调了将狗用作人类PCa新型临床前动物模型的可能性，从而带来可能使两个物种都受益的新疗法和诊断方法。
