与普通人群相比，非酒精性脂肪性肝病患者的合并症与恶性肿瘤：一项基于全国的研究

Comorbidities and Malignancy among NAFLD Patients Compared to the General Population, A Nation-Based Study.

作者信息

Abu-Freha Naim, Cohen Bracha, Gordon Michal, Weissmann Sarah, Fich Alexander, Munteanu Daniela, Yardeni David, Etzion Ohad

机构信息

The Institute of Gastroenterology and Hepatology, Soroka University Medical Center, Beer-Sheva 84101, Israel.

The Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.

出版信息

Biomedicines. 2023 Apr 6;11(4):1110. doi: 10.3390/biomedicines11041110.

DOI:10.3390/biomedicines11041110

PMID:37189727

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10136025/

Abstract

(1) Background: Non-alcoholic fatty liver disease (NAFLD) is a common liver disease. Aims: We aimed to investigate the frequency of comorbidities and malignancies among NAFLD patients compared to the general population. (2) Methods: A retrospective study included adult patients with a NAFLD diagnosis. A control group was matched for age and gender. Demographics, comorbidities, malignancies, and mortality were collected and compared. (3) Results: 211,955 NAFLD patients were analyzed in comparison to 452,012 matched general population controls. Significantly higher rates of diabetes mellitus (23.2% vs. 13.3%), obesity (58.8% vs. 27.8%), hypertension (57.2% vs. 39.9%), chronic ischemic heart disease (24.7% vs. 17.3%), and CVA (3.2% vs. 2.8%) were found among NAFLD patients. Patients with NAFLD had significantly higher rates of the following malignancies: prostate cancer (1.6% vs. 1.2%), breast cancer (2.6% vs. 1.9%), colorectal cancer (1.8% vs. 1.4%), uterine cancer (0.4 vs. 0.2%), kidney cancer (0.8% vs. 0.5%), but a lower rate of lung cancer (0.9% vs. 1.2%) and stomach cancer (0.3% vs. 0.4%). The all-cause mortality rate among NAFLD patients was significantly lower in comparison to the general population (10.8% vs. 14.7%, < 0.001). (4) Conclusions: Higher rates of comorbidities and malignancies among NAFLD patients were observed, but a lower rate of all-cause mortality was found.

摘要

(1) 背景：非酒精性脂肪性肝病（NAFLD）是一种常见的肝脏疾病。目的：我们旨在调查与普通人群相比，NAFLD患者中合并症和恶性肿瘤的发生率。(2) 方法：一项回顾性研究纳入了诊断为NAFLD的成年患者。设立一个年龄和性别匹配的对照组。收集并比较人口统计学、合并症、恶性肿瘤和死亡率数据。(3) 结果：对211,955例NAFLD患者进行了分析，并与452,012例匹配的普通人群对照组进行比较。发现NAFLD患者中糖尿病（23.2% 对13.3%）、肥胖（58.8% 对27.8%）、高血压（57.2% 对39.9%）、慢性缺血性心脏病（24.7% 对17.3%）和脑血管意外（CVA，3.2% 对2.8%）的发生率显著更高。NAFLD患者中以下恶性肿瘤的发生率显著更高：前列腺癌（1.6% 对1.2%）、乳腺癌（2.6% 对1.9%）、结直肠癌（1.8% 对1.4%）、子宫癌（0.4对0.2%）、肾癌（0.8% 对0.5%），但肺癌（0.9% 对1.2%）和胃癌（0.3% 对0.4%）的发生率较低。与普通人群相比，NAFLD患者的全因死亡率显著更低（10.8% 对14.7%，P<0.001）。(4) 结论：观察到NAFLD患者中合并症和恶性肿瘤的发生率较高，但全因死亡率较低。