Yuile Alexander, Lee Adrian, Moon Elizabeth A, Hudson Amanda, Kastelan Marina, Miller Samuel, Chan David, Wei Joe, Back Michael F, Wheeler Helen R
Department of Medical Oncology, Royal North Shore Hospital, Reserve Road, St Leonards, NSW 2065, Australia.
Faculty of Medicine and Health Sciences, Northern Clinical School, The University of Sydney, Sydney, NSW 2000, Australia.
Biomedicines. 2023 Apr 11;11(4):1148. doi: 10.3390/biomedicines11041148.
Glioblastomas are the most common and fatal primary brain malignancy in adults. There is a growing interest in identifying the molecular mechanisms of these tumors to develop novel treatments. Glioblastoma neo-angiogenesis is driven by VEGF, and another potential molecule linked to angiogenesis is PSMA. Our study suggests the potential for an association between PSMA and VEGF expression in glioblastoma neo-vasculature.
Archived wild-type glioblastomas were accessed; demographic and clinical outcomes were recorded. PSMA and VEGF expression by IHC were examined. Patients were dichotomized into PSMA expression high (3+) and low (0-2+) groups. The association between PSMA and VEGF expression was evaluated using Chi analysis. OS in PSMA high and low expression groups were compared using multi-linear regression.
In total, 247 patients with wild-type glioblastoma with archival tumor samples (between 2009-2014) were examined. PSMA expression correlated positively with VEGF expression ( = 0.01). We detected a significant difference in median OS between PSMA vascular endothelial expression high and low groups-16.1 and 10.8 months, respectively ( = 0.02).
We found a potential positive correlation between PSMA and VEGF expression. Secondly, we showed a potential positive correlation between PSMA expression and overall survival.
胶质母细胞瘤是成人中最常见且致命的原发性脑恶性肿瘤。人们对确定这些肿瘤的分子机制以开发新的治疗方法的兴趣与日俱增。胶质母细胞瘤的新生血管生成由血管内皮生长因子（VEGF）驱动，另一个与血管生成相关的潜在分子是前列腺特异性膜抗原（PSMA）。我们的研究表明PSMA与胶质母细胞瘤新生血管中VEGF表达之间可能存在关联。
获取存档的野生型胶质母细胞瘤；记录人口统计学和临床结果。通过免疫组化检测PSMA和VEGF的表达。患者被分为PSMA高表达（3+）和低表达（0-2+）组。使用卡方分析评估PSMA与VEGF表达之间的关联。使用多线性回归比较PSMA高表达和低表达组的总生存期（OS）。
总共检查了247例有存档肿瘤样本（2009年至2014年之间）的野生型胶质母细胞瘤患者。PSMA表达与VEGF表达呈正相关（P = 0.01）。我们检测到PSMA血管内皮高表达和低表达组的中位总生存期存在显著差异，分别为16.1个月和10.8个月（P = 0.02）。
我们发现PSMA与VEGF表达之间存在潜在的正相关。其次，我们表明PSMA表达与总生存期之间存在潜在的正相关。
