Ghafari Chadi, Brassart Nicolas, Delmotte Philippe, Brunner Philippe, Dghoughi Sarah, Carlier Stéphane
Department of Cardiology, Research Institute for Health Sciences and Technology, University of Mons (UMONS), 7000 Mons, Belgium.
CHU Ambroise Paré, 7000 Mons, Belgium.
Biomedicines. 2023 Apr 11;11(4):1150. doi: 10.3390/biomedicines11041150.
(1) Background: The diagnostic accuracy of coronary computed tomography angiography (CCTA) for coronary artery disease (CAD) has greatly improved so CCTA represents a transition in the care of patients suffering from CAD. Magnesium-based bioresorbable stents (Mg-BRS) secure acute percutaneous coronary intervention (PCI) results without leaving, in the long term, a metallic caging effect. The purpose of this real-world study was to assess clinical and CCTA medium- and long-term follow-up of all our patients with implanted Mg-BRS. (2) Methods: The patency of 52 Mg-BRS implanted in 44 patients with de novo lesions (24 of which had acute coronary syndrome (ACS)) was evaluated by CCTA and compared to quantitative coronary angiography (QCA) post-implantation. (3) Results: ten events including four deaths occurred during a median follow-up of 48 months. CCTA was interpretable and in-stent measurements were successful at follow-up without being hindered by the stent strut's "blooming effect". Minimal in-stent diameters on CCTA were found to be 1.03 ± 0.60 mm smaller than the expected diameter after post-dilation on implantation ( < 0.05), a difference not found in comparing CCTA and QCA. (4) Conclusions: CCTA follow-up of implanted Mg-BRS is fully interpretable and we confirm the long-term Mg-BRS safety profile.
(1) 背景：冠状动脉计算机断层扫描血管造影（CCTA）对冠状动脉疾病（CAD）的诊断准确性有了很大提高，因此CCTA代表了CAD患者护理模式的转变。镁基生物可吸收支架（Mg-BRS）可确保急性经皮冠状动脉介入治疗（PCI）的效果，且长期不会产生金属笼效应。本真实世界研究的目的是评估所有植入Mg-BRS患者的临床及CCTA中长期随访情况。(2) 方法：通过CCTA评估44例新发病变患者（其中24例患有急性冠状动脉综合征（ACS））植入的52个Mg-BRS的通畅情况，并与植入后定量冠状动脉造影（QCA）结果进行比较。(3) 结果：在中位随访48个月期间发生了10起事件，包括4例死亡。随访时CCTA可解读，支架内测量成功，未受支架支柱“伪像效应”的干扰。发现CCTA上的最小支架内直径比植入后后扩张预期直径小1.03±0.60mm（<0.05），在比较CCTA和QCA时未发现此差异。(4) 结论：植入Mg-BRS后的CCTA随访完全可解读，我们证实了Mg-BRS的长期安全性。
