Mostafa Ahmed M A, Zakaly Hesham M H, Issa Shams A M, Uosif Mohamed A M, Alrowaili Ziyad A, Zhukovsky Michael V
Physics Department, College of Science, Jouf University, Sakaka P.O. Box 2014, Saudi Arabia.
Institute of Physics and Technology, Ural Federal University, Ekaterinburg 620002, Russia.
Biomedicines. 2023 Apr 13;11(4):1173. doi: 10.3390/biomedicines11041173.
This study highlights the use of Zr-oxalate in diagnostic applications with the help of WinAct and IDAC2.1 software. It presents the biodistribution of the drug in various organs and tissues, including bone, blood, muscle, liver, lung, spleen, kidneys, inflammations, and tumors, and analyzes the maximum amount of nuclear transformation per Bq intake for each organ. The retention time of the maximum nuclear transformation and the absorbed doses of the drug in various organs and tissues are also examined. Data from clinical and laboratory studies on radiopharmaceuticals are used to estimate the coefficients of transition. The accumulation and excretion of the radiopharmaceutical in the organs is assumed to follow an exponential law. The coefficients of transition from the organs to the blood and vice versa are estimated using a combination of statistical programs and digitized data from the literature. WinAct and IDAC 2.1 software are used to calculate the distribution of the radiopharmaceutical in the human body and to estimate the absorbed doses in organs and tissues. The results of this study can provide valuable information for the biokinetic modeling of wide-spectrum diagnostic radiopharmaceuticals. The results show that Zr-oxalate has a high affinity for bones and a relatively low impact on healthy organs, making it helpful in targeting bone metastases. This study provides valuable information for further research on the development of this drug for potential clinical applications.
本研究强调了借助WinAct和IDAC2.1软件，草酸锆在诊断应用中的使用。它呈现了该药物在包括骨骼、血液、肌肉、肝脏、肺、脾脏、肾脏、炎症和肿瘤等各种器官和组织中的生物分布，并分析了每个器官每摄入1贝可的最大核转变量。还研究了最大核转变的保留时间以及该药物在各种器官和组织中的吸收剂量。来自放射性药物临床和实验室研究的数据用于估计转移系数。假定放射性药物在器官中的积累和排泄遵循指数规律。使用统计程序和文献中的数字化数据相结合的方法，估计从器官到血液以及从血液到器官的转移系数。WinAct和IDAC 2.1软件用于计算放射性药物在人体中的分布，并估计器官和组织中的吸收剂量。本研究结果可为广谱诊断放射性药物的生物动力学建模提供有价值的信息。结果表明，草酸锆对骨骼具有高亲和力，对健康器官的影响相对较低，这使其有助于靶向骨转移。本研究为进一步开发该药物用于潜在临床应用的研究提供了有价值的信息。
