人体注射 89Zr 标记单克隆抗体的剂量学评估。

Dosimetry Assessment of Injected 89Zr-Labeled Monoclonal Antibodies in Humans.

机构信息

a Ural Federal University, Ekaterinburg, Russia.

c Physics Department, Faculty of Science, Al-Azhar University, Assuit Branch, Assuit, Egypt.

出版信息

Radiat Res. 2019 May;191(5):466-474. doi: 10.1667/RR15321.1. Epub 2019 Mar 21.

DOI:10.1667/RR15321.1

PMID:30896281

Abstract

In this study, the behavior dynamics of Zirconium-89 (Zr)-labeled monoclonal antibodies (MAbs) after injection into the human body were modeled. This modified biokinetic model can be used for dose assessment, not only for Zr-labeled MAb tumor visualization, but also for diagnostic and therapeutic radiation with MAb labeled with other radionuclides. A modified biokinetic model was created based on experimental data from previously published studies. Cumulative Zr activity in organs and tissues per Bq of administered activity was calculated using the WinAct program. For most organs receiving the highest radiation dose, average absorbed doses were estimated using IDAC version 2.1 software. The results from the modeled calculations were compared with recently published results from studies of real patients. The calculations revealed that organs with the highest dose were the spleen, liver, kidneys and red bone marrow, at 1.54, 1.33, 0.81 and 0.82 mGy/MBq, respectively. In the modified biokinetic model, with MAb injection, organs exhibiting the highest dose were liver, heart wall, spleen, red bone marrow and pancreas, at 1.05, 0.93, 0.79, 0.69 and 0.67 mGy/MBq, respectively.

摘要

在这项研究中，模拟了注射入人体后的 89 锆（Zr）标记单克隆抗体（Mab）的行为动力学。这种改良的生物动力学模型可用于剂量评估，不仅可用于 Zr 标记的 Mab 肿瘤可视化，还可用于其他放射性核素标记的 Mab 的诊断和治疗辐射。基于先前发表的研究中的实验数据创建了改良的生物动力学模型。使用 WinAct 程序计算每 Bq 给予的活性的器官和组织中累积的 Zr 活性。对于接受最高辐射剂量的大多数器官，使用 IDAC 版本 2.1 软件估算平均吸收剂量。将模型计算的结果与最近发表的真实患者研究结果进行了比较。计算结果表明，剂量最高的器官是脾脏、肝脏、肾脏和红骨髓，分别为 1.54、1.33、0.81 和 0.82 mGy/MBq。在改良的生物动力学模型中，注射 Mab 后，肝脏、心脏壁、脾脏、红骨髓和胰腺的器官显示出最高的剂量，分别为 1.05、0.93、0.79、0.69 和 0.67 mGy/MBq。