Pijpers Adinda G H, de Beaufort Cunera M C, Maat Sanne C, Broers Chantal J M, Straver Bart, van Heurn Ernest, Gorter Ramon R, Derikx Joep P M
Department of Pediatric Surgery, Emma Children's Hospital Amsterdam UMC, Location University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Amsterdam Gastroenterology and Metabolism Research Institute, 1105 AZ Amsterdam, The Netherlands.
Children (Basel). 2023 Apr 5;10(4):688. doi: 10.3390/children10040688.
Congenital abdominal wall defects might be associated with other anomalies, such as atresia in gastroschisis and cardiac anomalies in omphalocele patients. However, in the current literature, an overview of these additional anomalies and potential patient-specific risk factors is missing. Therefore, we aimed to assess the prevalence of associated anomalies and their patient-specific risk factors in patients with gastroschisis and omphalocele.
A mono-center retrospective cohort study between 1997 and 2023 was performed. Outcomes were the presence of any additional anomalies. Risk factors were analyzed via logistic regression analysis.
In total, 122 patients were included, of whom 82 (67.2%) had gastroschisis, and 40 (32.8%) had omphalocele. Additional anomalies were identified in 26 gastroschisis patients (31.7%) and in 27 omphalocele patients (67.5%). In patients with gastroschisis, intestinal anomalies were most identified (n = 13, 15.9%), whereas, in patients with omphalocele, cardiac anomalies were most identified (n = 15, 37.5%). Logistic regression showed that cardiac anomalies were associated with complex gastroschisis (OR: 8.5; CI-95%: 1.4-49.5).
In patients with gastroschisis and omphalocele, intestinal and cardiac anomalies were most identified, respectively. Cardiac anomalies were found to be a risk factor for patients with complex gastroschisis. Therefore, regardless of the type of gastroschisis and/or omphalocele, postnatal cardiac screening remains important.
先天性腹壁缺损可能与其他异常有关，如腹裂患者的闭锁和脐膨出患者的心脏异常。然而，在当前文献中，缺少对这些额外异常和潜在患者特异性风险因素的概述。因此，我们旨在评估腹裂和脐膨出患者中相关异常及其患者特异性风险因素的患病率。
进行了一项1997年至2023年的单中心回顾性队列研究。结果是是否存在任何其他异常。通过逻辑回归分析来分析风险因素。
总共纳入了122例患者，其中82例（67.2%）患有腹裂，40例（32.8%）患有脐膨出。在26例腹裂患者（31.7%）和27例脐膨出患者（67.5%）中发现了其他异常。在腹裂患者中，肠道异常最为常见（n = 13，15.9%），而在脐膨出患者中，心脏异常最为常见（n = 15，37.5%）。逻辑回归显示，心脏异常与复杂腹裂相关（比值比：8.5；95%置信区间：1.4 - 49.5）。
在腹裂和脐膨出患者中，分别最常发现肠道和心脏异常。心脏异常被发现是复杂腹裂患者的一个风险因素。因此，无论腹裂和/或脐膨出的类型如何，产后心脏筛查仍然很重要。
