Post-Graduation Program of Cell Biology, Department of Morphology, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil.
Center for Research and Development of Drugs, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil.
Cells. 2023 Apr 11;12(8):1131. doi: 10.3390/cells12081131.
Dysregulated inflammatory responses are often correlated with disease severity during viral infections. Annexin A1 (AnxA1) is an endogenous pro-resolving protein that timely regulates inflammation by activating signaling pathways that culminate with the termination of response, clearance of pathogen and restoration of tissue homeostasis. Harnessing the pro-resolution actions of AnxA1 holds promise as a therapeutic strategy to control the severity of the clinical presentation of viral infections. In contrast, AnxA1 signaling might also be hijacked by viruses to promote pathogen survival and replication. Therefore, the role of AnxA1 during viral infections is complex and dynamic. In this review, we provide an in-depth view of the role of AnxA1 during viral infections, from pre-clinical to clinical studies. In addition, this review discusses the therapeutic potential for AnxA1 and AnxA1 mimetics in treating viral infections.
失调的炎症反应通常与病毒感染期间的疾病严重程度相关。膜联蛋白 A1（AnxA1）是一种内源性的促解决蛋白，通过激活信号通路来及时调节炎症反应，最终终止反应、清除病原体并恢复组织内稳态。利用 AnxA1 的促解决作用作为一种治疗策略来控制病毒感染的临床症状的严重程度具有广阔的前景。相反，AnxA1 信号也可能被病毒劫持以促进病原体的存活和复制。因此，AnxA1 在病毒感染期间的作用是复杂和动态的。在这篇综述中，我们从临床前研究到临床研究，深入探讨了 AnxA1 在病毒感染中的作用。此外，本文还讨论了 AnxA1 和 AnxA1 模拟物在治疗病毒感染方面的治疗潜力。
