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在1,2 - 二甲基肼诱导的肠道癌变实验模型中，紫檀芪与益生菌复合物对结直肠癌假定前驱病变的化学预防作用

Pterostilbene and Probiotic Complex in Chemoprevention of Putative Precursor Lesions for Colorectal Cancer in an Experimental Model of Intestinal Carcinogenesis with 1,2-Dimethylhydrazine.

作者信息

Barreira Márcio Alencar, Campelo Márcio Wilker Soares, da Silva Martins Rebouças Conceição, Duarte Antoniella Souza Gomes, Barbosa Maria Lucianny Lima, da Cruz Fonseca Said Gonçalves, Queiroz Raphaela Ribeiro, Holanda Érica Uchoa, de Vasconcelos Ana Beatriz Aragão, de Sousa Araújo Vitória Jannyne Guimarães, Diniz Gabriel Maia, Oriá Reinaldo Barreto, de Vasconcelos Paulo Roberto Leitão

机构信息

Walter Cantídio University Hospital, Federal University of Ceará, Fortaleza 60430-140, CE, Brazil.

Department of Surgery, School of Medicine, Federal University of Ceará, Fortaleza 60430-140, CE, Brazil.

出版信息

Cancers (Basel). 2023 Apr 21;15(8):2401. doi: 10.3390/cancers15082401.

DOI:10.3390/cancers15082401

PMID:37190329

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10136993/

Abstract

Dietary supplementation with pterostilbene (PS) and/or a probiotic (PRO) may ameliorate the intestinal microbiota in disease conditions. This study aims to evaluate PS and PRO for the chemoprevention of putative precursor lesions for colorectal cancer (CRC) in an experimental model of intestinal carcinogenesis with 1,2-dimethylhydrazine (1,2-DMH). Sixty male Wistar rats were equally divided into five groups: Sham, 1,2-DMH, 1,2-DMH + PS, 1,2-DMH + PRO, and 1,2-DMH + PS + PRO. PRO (5 × 10/mL) was offered in water, and PS (300 ppm) was provided in the diet ad libitum. 1,2-DMH (20 mg/kg/week) was administered for 15 consecutive weeks. In the 25th week, proctocolectomy was conducted. PRO alone and PRO combined with PS were the best intervention strategies to improve experimental 1,2-DMH-induced CRC regarding several parameters of carcinogenesis. Our findings may contribute to the development of novel preventive strategies for CRC and may help to identify novel modulators of colon carcinogenesis.

摘要

在疾病状态下，补充紫檀芪（PS）和/或益生菌（PRO）可能会改善肠道微生物群。本研究旨在评估PS和PRO在1,2 - 二甲基肼（1,2 - DMH）诱导的肠道致癌实验模型中对结直肠癌（CRC）假定前体病变的化学预防作用。将60只雄性Wistar大鼠平均分为五组：假手术组、1,2 - DMH组、1,2 - DMH + PS组、1,2 - DMH + PRO组和1,2 - DMH + PS + PRO组。通过饮水给予PRO（5×10⁹ / mL），并在饮食中随意提供PS（300 ppm）。连续15周每周给予1,2 - DMH（20 mg / kg）。在第25周进行直肠结肠切除术。就致癌作用的几个参数而言，单独使用PRO以及PRO与PS联合使用是改善实验性1,2 - DMH诱导的CRC的最佳干预策略。我们的研究结果可能有助于开发新的CRC预防策略，并可能有助于识别结肠癌发生的新型调节因子。