Department of Periodontics, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin University, Changchun 130021, China.
Department of Periodontics, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou 510182, China.
J Zhejiang Univ Sci B. 2023 Apr 15;24(5):373-386. doi: 10.1631/jzus.B2200576.
Periodontitis is a complex chronic inflammatory disease. The invasion of pathogens induces the inflammatory microenvironment in periodontitis. Cell behavior changes in response to changes in the microenvironment, which in turn alters the local inflammatory microenvironment of the periodontium through factors secreted by cells. It has been confirmed that periodontal ligament stem cells (PDLSCs) are vital in the development of periodontal disease. Moreover, PDLSCs are the most effective cell type to be used for periodontium regeneration. This review focuses on changes in PDLSCs, their basic biological behavior, osteogenic differentiation, and drug effects caused by the inflammatory microenvironment, to provide a better understanding of the influence of these factors on periodontal tissue homeostasis. In addition, we discuss the underlying mechanism in detail behind the reciprocal responses of PDLSCs that affect the microenvironment.
牙周炎是一种复杂的慢性炎症性疾病。病原体的侵袭诱导了牙周炎的炎症微环境。细胞行为会随着微环境的变化而改变，进而通过细胞分泌的因子改变牙周组织的局部炎症微环境。已经证实牙周韧带干细胞（PDLSCs）在牙周病的发展中至关重要。此外，PDLSCs 是用于牙周组织再生最有效的细胞类型。本综述重点关注炎症微环境引起的 PDLSCs 变化、其基本生物学行为、成骨分化和药物作用，以更好地了解这些因素对牙周组织稳态的影响。此外，我们还详细讨论了影响微环境的 PDLSCs 相互作用的潜在机制。
