Eckert F, Schmid L, Kradolfer D, Schmid U
Blut. 1986 Jul;53(1):11-9. doi: 10.1007/BF00320578.
Bone-marrow biopsies and smears from 59 patients with reactive plasmocytosis (22), multiple myeloma (24), solitary plasmocytoma (3) and monoclonal gammopathy of undetermined significance (MGUS) (10) were examined. To demonstrate cytoplasmic immunoglobulin the immunoperoxidase method was applied and evaluated quantitatively. Immunohistology yielded different ranges in kappa/lambda ratio for reactive plasmocytosis (0.4-3.5), multiple myeloma (less than or equal to 0.1 and greater than or equal to 11.2) and MGUS (0.2-3.0). As a result this method seems to be helpful in characterizing a plasmocytosis and distinguishing overt myeloma from monoclonal gammopathy of undetermined significance and reactive plasmocytosis. A differentiation of monoclonal gammopathy of undetermined significance from reactive plasmocytosis is not possible histologically and immunohistologically.
对59例反应性浆细胞增多症（22例）、多发性骨髓瘤（24例）、孤立性浆细胞瘤（3例）和意义未明的单克隆丙种球蛋白病（MGUS，10例）患者的骨髓活检和涂片进行了检查。为了显示细胞质免疫球蛋白，应用免疫过氧化物酶方法并进行定量评估。免疫组织学显示，反应性浆细胞增多症的κ/λ比值范围为0.4 - 3.5，多发性骨髓瘤的κ/λ比值范围为小于或等于0.1以及大于或等于11.2，MGUS的κ/λ比值范围为0.2 - 3.0。因此，该方法似乎有助于对浆细胞增多症进行特征描述，并将明显的骨髓瘤与意义未明的单克隆丙种球蛋白病和反应性浆细胞增多症区分开来。从组织学和免疫组织学上无法将意义未明的单克隆丙种球蛋白病与反应性浆细胞增多症区分开来。
