Shimizu K, Ohnishi K, Kunii A
Clin Exp Immunol. 1982 Dec;50(3):596-600.
Circulating immunoglobulin (Ig) secreting cells of each type of the different Ig classes were enumerated using a reverse haemolytic plaque assay in nine subjects with the pre-clinical phase of IgG myeloma (six with benign monoclonal gammopathy and three with smouldering multiple myeloma). A shift in the ratio of IgG kappa to IgG lambda secreting cells without a significant increase in the total number of IgG secreting cells, that is the number of IgG kappa plus IgG lambda secreting cells, was a constant feature noted in every subject.
在9例处于IgG骨髓瘤临床前期的患者(6例为良性单克隆丙种球蛋白病,3例为冒烟型多发性骨髓瘤)中,使用反向溶血空斑试验对不同Ig类别中每种类型的循环免疫球蛋白(Ig)分泌细胞进行计数。在每个受试者中均观察到一个恒定特征,即IgG κ分泌细胞与IgG λ分泌细胞的比例发生变化,而IgG分泌细胞总数(即IgG κ分泌细胞与IgG λ分泌细胞数量之和)无显著增加。