促性腺激素释放激素拮抗剂[D-焦谷氨酸1，D-苯丙氨酸2，D-色氨酸3,6]-促性腺激素释放激素对大鼠妊娠的影响。
Effect of the LRF-antagonist [D-pGlu1, D-Phe2, D-Trp3,6]-LRF on pregnancy in the rat.
作者信息
Rivier C, Rivier J, Vale W
出版信息
Contraception. 1979 Feb;19(2):185-90. doi: 10.1016/s0010-7824(79)80030-x.
PMID:371912
Abstract
The potent LRF-antagonist [D-pGlu1, D-Phe2, D-Trp3,6]-LRF (Antag.) has been examined for its effect in mated female rats. While 1.25 mg Antag. given b.i.d. for 7 days after mating prolongs pregnancy, the administration of 2.5 mg Antag. b.i.d. for the same period results in the complete absence of developing fetuses.
摘要
强效促黄体激素释放因子（LRF）拮抗剂[D-焦谷氨酸1，D-苯丙氨酸2，D-色氨酸3,6]-LRF（拮抗剂）对交配后的雌性大鼠的作用已进行了研究。交配后每天两次给予1.25毫克拮抗剂，持续7天可延长孕期，而同期每天两次给予2.5毫克拮抗剂则导致完全没有发育中的胎儿。
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