Department of Environmental and Radiological Health Sciences, Colorado State University, 1681 Campus Delivery, Fort Collins, CO, 80523-1681, USA.
Curr Allergy Asthma Rep. 2023 Jun;23(6):325-339. doi: 10.1007/s11882-023-01081-2. Epub 2023 May 16.
Exposure to bioaerosols at dairies has long been associated with allergy, respiratory disease, and decreases in lung function. Recent advancements in exposure assessments have aided our understanding on the size distribution and composition of these bioaerosols, but investigations focusing solely on exposures may overlook important intrinsic factors impacting worker's susceptibility to disease.
In our review, we discuss the most recent studies examining the exposures and genetic factors that contribute to occupational disease in dairy work. We also review more recent concerns in livestock work associated with zoonotic pathogens, antimicrobial resistant genes, and the role of the human microbiome. The studies highlighted in this review demonstrate the need for further research to better understand bioaerosol exposure-response relationships in the context of extrinsic and intrinsic factors, antibiotic-resistant genes, viral pathogens, and the human microbiome to help inform effective interventions that improve respiratory health among dairy farmers.
综述目的:长期以来,奶牛场的生物气溶胶暴露一直与过敏、呼吸道疾病和肺功能下降有关。最近在暴露评估方面的进展帮助我们了解了这些生物气溶胶的大小分布和组成,但仅关注暴露的研究可能会忽略影响工人患病易感性的重要内在因素。
最近发现:在本综述中,我们讨论了最近研究考察了在奶牛场工作中导致职业疾病的暴露和遗传因素。我们还回顾了与人畜共患病原体、抗微生物药物耐药基因以及人类微生物组相关的最近在畜牧业工作中的关注点。本综述中强调的研究表明需要进一步研究,以更好地了解在外在和内在因素、抗生素耐药基因、病毒病原体和人类微生物组背景下的生物气溶胶暴露反应关系,以帮助提供有效的干预措施,改善奶牛场工人的呼吸健康。