瞬时受体电位锚蛋白1通道在温度感觉中的作用。
The role of TRPA1 channels in thermosensation.
作者信息
Zhang Hao, Wang Chengsan, Zhang Keyi, Kamau Peter Muiruri, Luo Anna, Tian Lifeng, Lai Ren
机构信息
Key Laboratory of Animal Models and Human Disease Mechanisms, Key Laboratory of Bioactive Peptides of Yunnan Province, Engineering Laboratory of Bioactive Peptides, National & Local Joint Engineering Center of Natural Bioactive Peptides, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Resource Center for Non-Human Primates, Kunming Primate Research Center, and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650107, Yunnan, China.
University of Chinese Academy of Sciences, Beijing, 100049, China.
出版信息
Cell Insight. 2022 Oct 11;1(6):100059. doi: 10.1016/j.cellin.2022.100059. eCollection 2022 Dec.
Transient receptor potential ankyrin 1 (TRPA1) is a polymodal nonselective cation channel sensitive to different physical and chemical stimuli. TRPA1 is associated with many important physiological functions in different species and thus is involved in different degrees of evolution. TRPA1 acts as a polymodal receptor for the perceiving of irritating chemicals, cold, heat, and mechanical sensations in various animal species. Numerous studies have supported many functions of TRPA1, but its temperature-sensing function remains controversial. Although TRPA1 is widely distributed in both invertebrates and vertebrates, and plays a crucial role in tempreture sensing, the role of TRPA1 thermosensation and molecular temperature sensitivity are species-specific. In this review, we summarize the temperature-sensing role of TRPA1 orthologues in terms of molecular, cellular, and behavioural levels.
瞬时受体电位锚蛋白1（TRPA1）是一种对不同物理和化学刺激敏感的多模态非选择性阳离子通道。TRPA1与不同物种的许多重要生理功能相关，因此参与了不同程度的进化。TRPA1作为一种多模态受体，可感知各种动物物种中的刺激性化学物质、冷、热和机械感觉。大量研究支持了TRPA1的多种功能，但其温度传感功能仍存在争议。尽管TRPA1广泛分布于无脊椎动物和脊椎动物中，并在温度传感中起关键作用，但TRPA1热感觉的作用和分子温度敏感性具有物种特异性。在本综述中，我们从分子、细胞和行为水平总结了TRPA1直系同源物的温度传感作用。
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