Bland S K, Bland B H
Brain Res. 1986 Jun 4;375(1):102-16. doi: 10.1016/0006-8993(86)90963-7.
The effect of small electrolytic lesions in various areas of the septum on the behavioral correlates and firing repertoires of hippocampal theta cells, was investigated in the freely moving rabbit. Lesions localized to the medial septum were found to abolish both slow wave theta and the rhythmic firing of CA1 and dentate layer theta cells, in both the type 1 theta (movement) and type 2 theta (sensory processing) behavior conditions. Small lesions of the diagonal band, lateral septum and fimbria/fornix regions only affected rhythmicity to the extent that they also involved the medial septal region. The same medial septal lesions that abolished rhythmicity were also shown to reduce the mean discharge rate of theta cells occurring during the type 1 movement condition by approximately 50%, while the discharge rate occurring during the type 2 sensory processing condition did not change significantly. Behavioral changes were also only observed for lesions involving the medial septum. The importance of afferent input from the medial septum in the generation of hippocampal theta cell rhythmicity was discussed.
在自由活动的兔子身上，研究了在隔膜不同区域进行小的电解损伤对海马θ细胞的行为相关性和放电模式的影响。发现在1型θ（运动）和2型θ（感觉处理）行为条件下，位于内侧隔膜的损伤会消除慢波θ以及CA1和齿状层θ细胞的节律性放电。对角带、外侧隔膜和穹窿/穹窿区域的小损伤仅在它们也涉及内侧隔膜区域的程度上影响节律性。消除节律性的相同内侧隔膜损伤也显示出在1型运动条件下发生的θ细胞平均放电率降低了约50%，而在2型感觉处理条件下发生的放电率没有显著变化。行为变化也仅在涉及内侧隔膜的损伤中观察到。讨论了来自内侧隔膜的传入输入在海马θ细胞节律性产生中的重要性。
