Department of Neonatology, The First People's Hospital of Wenling, No.333, Chuanan South Road, Chengxi Street, Wenling, 317500, Zhejiang, China.
Naunyn Schmiedebergs Arch Pharmacol. 2023 Oct;396(10):2369-2377. doi: 10.1007/s00210-023-02439-z. Epub 2023 May 17.
Acute lung injury (ALI) is a major pathophysiological problem defined by severe inflammation and acute disease with substantial morbidity and death. It is known that lipopolysaccharide (LPS) induces ALI by causing oxidative stress and inflammation. The goal of this study was to investigate the protective effect of astringin on LPS-induced ALI and probable pathways. Astringin is a stilbenoid, the 3-β-D-glucoside of piceatannol, mainly found in the bark of Picea sitchensis. The findings showed that astringin prevented LPS-induced cellular damage by reducing the generation of oxidative stress in LPS-stimulated A549 lung epithelial cells. Furthermore, astringin extensively decreased the production of inflammatory factors such as TNF-α, IL-1β, and IL-6. In addition, the western blot results revealed that the ability of astringin to reduce oxidative stress and the generation of inflammatory cytokines by inhibiting the ROS-mediated PI3K/AKT/NF-κB pathway could be the reason for its protective effect against LPS-induced ALI. Overall, the results suggest that astringin could be a possible inhibitor of ALI triggered by LPS for pediatric lung injury.
急性肺损伤（ALI）是一种主要的病理生理问题，其特征为严重炎症和急性疾病，发病率和死亡率高。已知脂多糖（LPS）通过引起氧化应激和炎症导致 ALI。本研究的目的是探讨鞣花酸对 LPS 诱导的 ALI 及可能途径的保护作用。鞣花酸是一种二苯乙烯类化合物，是白皮松素的 3-β-D-葡萄糖苷，主要存在于白云杉的树皮中。研究结果表明，鞣花酸通过减少 LPS 刺激的 A549 肺上皮细胞中氧化应激的产生，预防 LPS 诱导的细胞损伤。此外，鞣花酸还广泛降低了 TNF-α、IL-1β 和 IL-6 等炎症因子的产生。此外，Western blot 结果表明，鞣花酸通过抑制 ROS 介导的 PI3K/AKT/NF-κB 通路来减少氧化应激和炎症细胞因子的产生，这可能是其对 LPS 诱导的 ALI 保护作用的原因。总的来说，这些结果表明，鞣花酸可能是 LPS 触发的小儿肺损伤的 ALI 的一种潜在抑制剂。
