苯并三氮唑-1-酮的合成通过异邻苯二甲酰亚胺与腈亚胺的脱羧[4 + 3]-环加成反应。
Synthesis of Benzotriazepin-1-ones via Decarboxylative [4 + 3]-Annulation of Isatoic Anhydrides with Nitrile Imines.
机构信息
Department of Chemistry, College of Natural Science, Kyonggi University, 154-42 Gwanggyosan-ro, Yeongtong-gu, Suwon 16227, Republic of Korea.
出版信息
J Org Chem. 2023 Jun 2;88(11):7290-7301. doi: 10.1021/acs.joc.3c00524. Epub 2023 May 17.
A novel and streamlined approach to synthesizing benzotriazepin-1-ones has been developed through a hexafluoroisopropanol-promoted decarboxylative cascade reaction between isatoic anhydrides and hydrazonoyl chloride. The [4 + 3] annulation of hexafluoroisopropyl 2-aminobenzoates with nitrile imines, generated in situ, is a key feature of this innovative reaction. This approach has offered a simple and efficient method for synthesizing a broad range of structurally intricate and highly functional benzotriazepinones.
通过六氟异丙醇促进的异邻苯二甲酰亚胺和酰肼氯之间的脱羧级联反应，开发了一种新颖而简化的苯并三唑-1-酮合成方法。六氟异丙基 2-氨基苯甲酸酯与原位生成的腈亚胺的[4+3]环加成是该创新反应的关键特征。这种方法为合成广泛的结构复杂和高度功能化的苯并三唑-1-酮提供了一种简单有效的方法。
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