Division of Epidemiology and Medical Statistics, School of Public Health, Nantong University, Nantong, Jiangsu, China.
Department of Occupational Environmental Toxicology, School of Public Health, Nantong University, Nantong, Jiangsu, China.
PLoS One. 2023 May 17;18(5):e0285623. doi: 10.1371/journal.pone.0285623. eCollection 2023.
To explore the relationship between changing occupational stress levels, hair cortisol concentration (HCC), and hypertension.
Baseline blood pressure of 2520 workers was measured in 2015. The Occupational Stress Inventory-Revised Edition (OSI-R) was used to assess changes in occupational stress. Occupational stress and blood pressure were followed up annually from January 2016 to December 2017. The final cohort numbered 1784 workers. The mean age of the cohort was 37.77±7.53 years and the percentage male was 46.52%. At baseline, 423 eligible subjects were randomly selected for hair sample collection to determine cortisol levels.
Increased occupational stress was a risk factor for hypertension [risk ratio (RR) = 4.200, 95% confidence interval (CI): 1.734-10.172]. The HCC of workers with elevated occupational stress was higher than that of workers with constant occupational stress [(ORQ score ≥70: geometric mean±geometric standard deviation = 5.25±3.59 ng/g hair; 60-90: 5.02±4.00; 40-59: 3.45±3.41; <40: 2.73±3.40) x2 = 5.261]. High HCC increased the risk of hypertension (RR = 5.270, 95% CI: 2.375-11.692) and high HCC was associated with higher rates of elevated diastolic and systolic blood pressure. The mediating effect of HCC was 0.51[(95% CI: 0.23-0.79, odds ratio(OR) = 1.67] and accounted for 36.83% of the total effect.
Increased occupational stress could lead to an increase in hypertension incidence. High HCC could increase the risk of hypertension. HCC acts as a mediator between occupational stress and hypertension.
探讨职业应激水平变化、头发皮质醇浓度（HCC）与高血压之间的关系。
2015 年对 2520 名工人进行了基础血压测量。使用职业应激量表修订版（OSI-R）评估职业应激变化。从 2016 年 1 月至 2017 年 12 月，每年对职业应激和血压进行随访。最终队列包括 1784 名工人。队列的平均年龄为 37.77±7.53 岁，男性比例为 46.52%。基线时，随机选择 423 名符合条件的受试者进行头发样本采集以确定皮质醇水平。
职业应激增加是高血压的危险因素[风险比（RR）=4.200，95%置信区间（CI）：1.734-10.172]。职业应激升高的工人 HCC 高于职业应激不变的工人[(ORQ 评分≥70：几何均数±几何标准差=5.25±3.59ng/g 头发；60-90：5.02±4.00；40-59：3.45±3.41；<40：2.73±3.40) x2=5.261]。高 HCC 增加了高血压的风险（RR=5.270，95%CI：2.375-11.692），且高 HCC 与舒张压和收缩压升高的发生率较高有关。HCC 的中介效应为 0.51[（95%CI：0.23-0.79，比值比（OR）=1.67]，占总效应的 36.83%。
职业应激增加可导致高血压发病率增加。高 HCC 可能增加高血压的风险。HCC 是职业应激与高血压之间的中介。
