再灌注时急性大剂量二甲双胍治疗可减小高危老龄心脏的梗死面积。
Acute, High Dose Metformin Therapy at Reperfusion Decreases Infarct Size in the High-Risk Aging Heart.
作者信息
Bates Lauryn, Krause-Hauch Meredith, Wang Hao, Fatmi Mohammad Kasim, Li Zehui, Chen Qun, Ren Di, Li Ji, Lesnefsky Edward J
机构信息
Department of Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA.
出版信息
Aging Dis. 2023 Oct 1;14(5):1488-1491. doi: 10.14336/AD.2023.0205.
Elderly patients (age > 75) sustain larger infarcts with greater mortality from ST elevation myocardial infarcts (STEMI) despite successful reperfusion treatment. Elderly age remains an independent risk despite correction for clinical and angiographic variables. The elderly represent a high-risk population and may benefit from treatment in addition to reperfusion alone. We hypothesized that modulation of cardiac signaling and metabolism with acute, high dose metformin given at reperfusion would exhibit additional cardioprotection. Using a translational aging murine model (22-24-month C57BL/6J mice) of in vivo STEMI (45 min artery occlusion with reperfusion for 24 hours); treatment acutely at reperfusion by high dose metformin decreased infarct size and enhanced contractile recovery, demonstrating cardioprotection in the high-risk aging heart.
老年患者（年龄>75岁）发生ST段抬高型心肌梗死（STEMI）时，尽管进行了成功的再灌注治疗，但梗死面积更大，死亡率更高。尽管校正了临床和血管造影变量，老年仍是一个独立的风险因素。老年人是高危人群，除单纯再灌注治疗外，可能还会从其他治疗中获益。我们假设，在再灌注时给予急性、高剂量二甲双胍来调节心脏信号传导和代谢，会表现出额外的心脏保护作用。使用体内STEMI的转化衰老小鼠模型（22 - 24月龄C57BL/6J小鼠，动脉闭塞45分钟后再灌注24小时）；在再灌注时通过高剂量二甲双胍进行急性治疗可减小梗死面积并增强收缩功能恢复，表明对高危衰老心脏具有心脏保护作用。
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