Waldrop T G, Ordway G A
Cardiovasc Res. 1986 Apr;20(4):312-6. doi: 10.1093/cvr/20.4.312.
The application of bradykinin or other algesic substances to the serosal surface of the gall bladder or the pancreas evokes reflex increases in cardiovascular function. The purpose of the present study was to determine whether prostaglandins modulate these reflex responses when visceral receptors are activated by bradykinin. The application of bradykinin or capsaicin to the gall bladder and the pancreas initially elicited increases in arterial pressure in anaesthetised cats. Local inhibition of prostaglandin synthesis with indomethacin greatly attenuated the pressor response to activation of gall bladder or pancreatic receptors by bradykinin. The pressor response to capsaicin was not altered by indomethacin. Thus prostaglandins appear to be involved in the activation of visceral receptors by bradykinin, which results in an increase in cardiovascular function.
将缓激肽或其他致痛物质应用于胆囊或胰腺的浆膜表面会引起心血管功能的反射性增强。本研究的目的是确定当内脏感受器被缓激肽激活时，前列腺素是否会调节这些反射反应。将缓激肽或辣椒素应用于胆囊和胰腺，最初会引起麻醉猫的动脉血压升高。用吲哚美辛局部抑制前列腺素合成可大大减弱缓激肽激活胆囊或胰腺感受器所引起的升压反应。吲哚美辛对辣椒素引起的升压反应没有影响。因此，前列腺素似乎参与了缓激肽对内脏感受器的激活，从而导致心血管功能增强。
