Wilkinson D L, Scroop G C
Eur J Pharmacol. 1985 Jul 17;113(2):287-90. doi: 10.1016/0014-2999(85)90749-6.
Vertebral and carotid artery infusions of bradykinin increased blood pressure and heart rate in anaesthetised greyhounds. Indomethacin pretreatment abolished the pressor response to vertebral infusion and reduced that to carotid infusion. Areas postrema ablation abolished the pressor response to bradykinin with both routes of administration. The tachycardia responses to cranial artery infusions and the entire cardiovascular response to intravenous infusion were unaffected by either treatment. It is concluded that intact areas postrema and normal prostaglandin synthesis are essential for the full expression of the central pressor action of bradykinin.
在麻醉的灵缇犬中，向椎动脉和颈动脉注射缓激肽可使血压和心率升高。吲哚美辛预处理消除了对椎动脉注射的升压反应，并降低了对颈动脉注射的升压反应。延髓后区切除消除了两种给药途径下缓激肽的升压反应。对颅动脉注射的心动过速反应以及对静脉注射的整个心血管反应均不受任何一种处理的影响。得出的结论是，完整的延髓后区和正常的前列腺素合成对于缓激肽中枢升压作用的充分发挥至关重要。
